Results 91 to 100 of about 4,135 (194)

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. [PDF]

, 2018
The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes.
Collins, Jeffrey, Drake, Christopher, Schopf, Eric, Slavik, Roger, van Dam, R Michael, Waldmann, Christopher M   +5 more
core  

Discovery the Mechanism of Qingdi Mixture for Radiation‐Induced Lung Injury Based on Network Pharmacology, Clinical Retrospective Analysis and Experimental Validation

Thoracic Cancer, Volume 16, Issue 19, October 2025.
Radiation‐induced lung injury (RILI) is a common complication of thoracic radiotherapy, and Qingdi mixture (QDM) has shown efficacy in its prevention. Through network pharmacology, molecular docking, and experimental validation, QDM was found to mitigate RILI primarily by inhibiting the NF‐κB signaling pathway and reducing inflammatory cytokines ...
Haoran Liu, Zhuang Yu, Qiancheng Lu, Yuke Mao, Qingzheng Liu, Shengnan Ren, Miao Zhang, Hongzong Si, Jing Wang   +8 more
wiley   +1 more source

Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis [PDF]

, 2018
The research leading to these results received funding from the Obra Social “la Caixa” (to ME), the Cellex Foundation (to ME), the European Union's Horizon 2020 research and innovation programme under grant agreement No 727264 Epipharm (to ME), the 2015 ...
Calleja Cervantes, M. E., Duruisseaux, M., Fernández Fernández, Agustín, Fernández Fraga, Mario, Martínez Cardús, A.   +4 more
core   +1 more source

Update on Genetic Chorea

European Journal of Neurology, Volume 32, Issue 10, October 2025.
This review provides an updated clinical and genetic framework for the differential diagnosis of hereditary chorea. It guides neurologists through the interpretation of phenomenology, ancillary tests, and appropriate genetic techniques to achieve an accurate and timely diagnosis.
Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Sara Bernal, Javier Pagonabarraga, Jaime Kulisevsky   +5 more
wiley   +1 more source

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

Journal of Pharmacological Sciences, 2010
Dopamine plays a central role in the regulation of psychomotor functions. The effect of dopamine is largely mediated through the cAMP/PKA signaling cascade and therefore controlled by phosphodiesterases (PDEs).
Akinori Nishi, Gretchen L. Snyder
doaj   +1 more source

Genome-Wide Association of Genetic Variants With Refraction, Axial Length, and Corneal Curvature: A Longitudinal Study of Chinese Schoolchildren

Frontiers in Genetics, 2020
BackgroundMyopia is a common eye disorder that is approaching epidemic proportions worldwide. A genome-wide association study identified AREG (rs12511037), GABRR1 (rs13215566), and PDE10A (rs12206610) as being associated with refractive error in Asian ...
Yaoyao Lin, Yu Ding, Dandan Jiang, Chunchun Li, Xiaoqiong Huang, Linjie Liu, Haishao Xiao, Balamurali Vasudevan, Yanyan Chen   +8 more
doaj   +1 more source

Quantitative metrics for drug-target ligandability. [PDF]

, 2018
Ligandability is a prerequisite for druggability and is a much easier concept to understand, model and predict because it does not depend on the complex pharmacodynamic and pharmacokinetic mechanisms in the human body.
Huggins, David J, Vukovic, Sinisa
core   +1 more source

Colorectal Neoplasia Pathogenesis in Normal Appearing Colonic Mucosa ‐A Perspective With Focus on Eicosanoid Signaling Pathways

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Colorectal cancer (CRC) is a major cause of cancer‐related mortality, especially in the Western world, and its incidence is expected to increase in the years to come. Prevention and early detection are key strategies to improve CRC morbidity and mortality.
Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Victoria Hellen Berner‐Hansen, Simon Veedfald, Mark Berner‐Hansen, Niels Bindslev   +5 more
wiley   +1 more source

Nurr1 protein is required for N-Methyl-d-aspartic Acid (NMDA) receptor-mediated neuronal survival [PDF]

, 2012
NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop.
Badiola Benito, Nahuai, Barneda Zahonero, Bruna, Fadó, Rut, Miñano Molina, Alfredo Jesús, Rodríguez Álvarez, José, Saura Antolín, Carlos A., Servitja i Duque, Joan-Marc   +6 more
core   +2 more sources

Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives

Molecules, 2020
In this study, a series of compounds derived from 4-methoxy-1H-isoindole-1,3(2H)-dione, potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics.
Anna Czopek, Anna Partyka, Adam Bucki, Maciej Pawłowski, Marcin Kołaczkowski, Agata Siwek, Monika Głuch-Lutwin, Paulina Koczurkiewicz, Elżbieta Pękala, Anna Jaromin, Bożena Tyliszczak, Anna Wesołowska, Agnieszka Zagórska   +12 more
doaj   +1 more source