Results 141 to 150 of about 4,135 (194)

Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathies. [PDF]

Brain
Nido GS, Castelli M, Mostafavi S, Rubiolo A, Shadad O, Alves G, Tysnes OB, Flønes IH, Dölle C, Tzoulis C.   +9 more
europepmc   +1 more source

Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia

, 2012
Neil S. Cutshall, René Onrust, Alex Rohde, Sasha Gragerov, Lauren E Hamilton, Kevin Harbol, Hui‐Rong Shen, S. P. Mc Kee, Charles Zuta, Galina Gragerova, Vince Florio, Thomas N. Wheeler, Jennifer L. Gage   +12 more
openalex   +1 more source

Roles of Inflammasomes in Inflammatory Responses and Human Diseases. [PDF]

Int J Mol Sci
Yi YS.
europepmc   +1 more source

Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy [PDF]

, 2016
Christine P. Diggle, Stacey J. Sukoff Rizzo, Michael Popiolek, Reetta Hinttala, Jan-Philip Schülke, Manju A. Kurian, Ian Carr, Alexander F. Markham, David T. Bonthron, Christopher M. Watson, Saghira Malik Sharif, Veronica Reinhart, Larry C. James, Michelle Vanase‐Frawley, Erik I. Charych, Melanie Allen, John F. Harms, Christopher J. Schmidt, Joanne Ng, Karen Pysden, Christine A. Strick, Päivi Vieira, Katariina Mankinen, Hannaleena Kokkonen, Matti Kallioinen, Raija Sormunen, Juha O. Rinne, Jarkko Johansson, Kati Alakurtti, Laura Huilaja, Tiina Hurskainen, Kaisa Tasanen, Eija Anttila, Tiago Reis Marques, Oliver Howes, Marius Politis, Somayyeh Fahiminiya, Khanh Q. Nguyen, Jacek Majewski, Johanna Uusimaa, Eamonn Sheridan, Nicholas J. Brandon   +41 more
openalex   +1 more source

Trapped in Silence: Severe Catatonia From Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis in a Neurofibromatosis Type 1 Patient With Craniopharyngioma. [PDF]

Cureus
Gebreselassie KZ, Negash T, Bravo PA, Chiu W.   +3 more
europepmc   +1 more source

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

, 2015
Jeffrey Varnes, Stefan Geschwindner, Christopher R. Holmquist, Janet M. Forst, Xia Wang, Niek Dekker, Clay W. Scott, Gaochao Tian, Michael W. Wood, Jeffrey S. Albert   +9 more
openalex   +1 more source

S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS [PDF]

, 2018
Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, Atsushi Nakatani, Clizia Capuani, Annarosa Ugolini, Mauro Corsi, Nidhi Kaushal, Konstantin Bobkov, John Vekich, Joseph Doyle, Haruhide Kimura   +11 more
openalex   +1 more source

Novel potential neuroprotective targets for DengZhanXiXin injection in middle cerebral artery occlusion rats recommended by quantitative proteomics and simulated docking. [PDF]

Front Neurosci
Li M, Wang L, An H, Li X, Chen Y, Wei D, Zhang Z.   +6 more
europepmc   +1 more source

Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling

, 2021
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia George Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Yan Chen   +8 more
openalex   +2 more sources

Comparative analysis of PDE10A isoforms [PDF]

, 2011
Corina Russwurm, Ronald Jäger, Doris Koesling, Michael Russwurm   +3 more
openalex   +1 more source