Results 141 to 150 of about 217,226 (371)

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender   +2 more
wiley   +1 more source

PDE-DKL: PDE-constrained deep kernel learning in high dimensionality

open access: yes
Many physics-informed machine learning methods for PDE-based problems rely on Gaussian processes (GPs) or neural networks (NNs). However, both face limitations when data are scarce and the dimensionality is high. Although GPs are known for their robust uncertainty quantification in low-dimensional settings, their computational complexity becomes ...
Yan, Weihao   +2 more
openaire   +3 more sources

Do Medication Beliefs Influence Adherence to Topical Therapies in Patients With Atopic Dermatitis?

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 10–20% of the global population and is characterized by red, itchy, and dry skin. While consistent medication adherence is necessary for adequate management of AD, patients' adherence to topical therapies can decline by 70% within initial days of treatment ...
Vivien Wen Ting Tai   +3 more
wiley   +1 more source

LE-PDE++: Mamba for accelerating PDEs Simulations

open access: yes
Partial Differential Equations are foundational in modeling science and natural systems such as fluid dynamics and weather forecasting. The Latent Evolution of PDEs method is designed to address the computational intensity of classical and deep learning-based PDE solvers by proposing a scalable and efficient alternative.
Liang, Aoming   +5 more
openaire   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

Advances and Current Progress of Dopant Engineering on All‐Inorganic Halide Perovskites Toward High‐Performance Scintillating Materials

open access: yesMetalMat, EarlyView.
This review provides the latest advancement on lead‐free all‐inorganic perovskites, covering fundamental aspects, emerging synthetic routes, and scintillation properties. We highlight the dopant engineering strategy to favor the formation and efficient radiative recombination of self‐trapped excitons and the future development direction for the next ...
Galfin Anderias Adu   +6 more
wiley   +1 more source

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