Results 171 to 180 of about 217,226 (371)
Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A
Phytotherapy Research, EarlyView.ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen +16 more
wiley +1 more source
COMPARING SIMULATIONS FROM COMPARTMENTAL AND CLASSIC PDE APPROACHES TO MODEL DRYING OF FOOD SOLIDS
, 2014 Hédi Romdhana +3 more
openalex +1 more source
Quarterly Journal of the Royal Meteorological Society, EarlyView.This study presents improvements to the non‐hydrostatic version of the European Centre for Medium‐Range Weather Forecasts (ECMWF) Integrated Forecasting System (IFS), enabling stable global simulations at 1.4‐km resolution. A systematic comparison with the hydrostatic version at resolutions from 9 to 1.4 km shows that non‐hydrostatic effects emerge in ...
Jozef Vivoda +3 more
wiley +1 more source
Convergence analysis of the Magnus-Rosenbrock type method for the finite element discretization of semilinear non-autonomous parabolic PDEs with nonsmooth initial data [PDF]
, 2018 Antoine Tambue, Jean Daniel Mukam
openalex +1 more source
A Discretize-then-Optimize Approach to PDE-Constrained Shape Optimization
, 2023 Roland Herzog, Estefanía Loayza-Romero
openalex +1 more source
Adenosine A2A receptor (ADORA2A); phosphodiesterase-2 (PDE-2); PDE-3; PDE-4; PDE-7 [PDF]
Science-Business eXchange, 2010 openaire +1 more source
Respirology, EarlyView.ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley +1 more source
Adaptive Sliding‐Mode Control of a Perturbed Diffusion Process With Pointwise In‐Domain Actuation
International Journal of Robust and Nonlinear Control, EarlyView.ABSTRACT A sliding mode–based adaptive control law is proposed for a class of diffusion processes featuring a spatially‐varying uncertain diffusivity and equipped with several point‐wise actuators located at the two boundaries of the spatial domain as well as in its interior.
Paul Mayr +3 more
wiley +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley +1 more source
CAAI Transactions on Intelligence Technology, EarlyView.ABSTRACT This paper proposes a boundary control method for nonlinear distributed parameter systems (DPSs) with limited boundary measurements (BMs), as typically encountered in networked cyber‐physical processes with spatially distributed dynamics such as thermal and biomedical diffusion systems.
Yanlin Li +5 more
wiley +1 more source