Results 191 to 200 of about 217,226 (371)

A fission yeast-based platform for nematode PDE inhibitor discovery. [PDF]

Cell Signal
Bibeau S, Chen N, Sutoris H, Ly J, Eberhard J, Hubbell SM, Banda E, Povh E, Anindya CS, Berwanger MR, Sinise SE, Zhang X, Morken JP, Galande KK, Cote RH, Dranchak PK, Inglese J, Hoffman CS.   +17 more
europepmc   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Peritoneal exosomes mediate activation of CD4⁺ T cells and enhancement of vaccine efficacy in teleost. [PDF]

Cell Commun Signal
Shi X, Jiang L, Ye M, Yanglang A, Mikkelborg MK, Tang X, Xing J, Sheng X, Zhan W, Dalmo RA, Chi H.   +10 more
europepmc   +1 more source

Contour integral methods for elliptic PDEs

, 2015
André Weideman
openalex   +1 more source

Parareal Convergence for Oscillatory PDEs with Finite Time-Scale Separation [PDF]

, 2019
Adam Peddle, Terry Haut, Beth Wingate
openalex   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Development of functional cheese sticks using konjac glucomannan: regulated pickering double emulsions under different heat treatments. [PDF]

Food Chem X
Xu W, Kang M, Zhang L, Yin Y, Luo D, Zhang X, Zhang L, Li L, Du S.   +8 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Characterisation of Bespoke Patient-Derived In Vitro Models of Ewing Sarcoma. [PDF]

Cancers (Basel)
Roundhill EA, Vasconcelos EJR, Davies J, Burchill SA.   +3 more
europepmc   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source