Results 121 to 130 of about 166,339,283 (190)

What Causes Geographic Variation in Drug Prescribing? Evidence from Physician Migration

The RAND Journal of Economics, Volume 57, Issue 3, Page 601-626, Autumn (Fall) 2026.
ABSTRACT In this article, we examine the importance of individual physicians in explaining the significant variation in prescription drug spending in Medicare Part D. By tracking prescribing behavior before and after physician relocations, we find that movers' prescribing converges toward the average of their new location.
David Beheshti, Seth Neller
wiley   +1 more source

Deterministic, stochastic, and mean-field PDE models in neuroscience. [PDF]

Front Comput Neurosci
Çetin C, Piqueira JRC, İzgi B, Peker-Dobie A, Ahmetolan S, Özkaya M.   +5 more
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Going with the flow to solve for symmetry-driven PDE dynamics with physics-informed neural networks. [PDF]

Nat Commun
Kavousanakis ME, Fabiani G, Georgiou AS, Siettos C, Kevrekidis PG, Kevrekidis IG.   +5 more
europepmc   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

New analytical wave solutions for the gardner equation via the Riccati-modified extended simple equation method. [PDF]

Sci Rep
Jawarneh Y, Almusawa MY, Haleemzai I, Hakami AH, Ahmadini AAH, Albaity A.   +5 more
europepmc   +1 more source

Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3243-3259, September 2026.
Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng, Gen Li, Man Zhou, Rushil Mandlik, Doris Wang, Yiping Qi   +5 more
wiley   +1 more source

Divergent viral phosphodiesterases for immune signaling evasion. [PDF]

Cell Host Microbe
Doherty EE, Nomburg J, Adler BA, Lopez S, Hsieh K, Price N, Blount N, Doudna JA.   +7 more
europepmc   +1 more source

Isometric immersions into three‐dimensional unimodular metric Lie groups

Journal of the London Mathematical Society, Volume 114, Issue 3, September 2026.
Abstract We study isometric immersions of surfaces into simply connected three‐dimensional unimodular Lie groups endowed with either Riemannian or Lorentzian left‐invariant metrics, assuming that Milnor's operator is diagonalizable in the Lorentzian case.
Ildefonso Castro, José M. Manzano, José S. Santiago   +2 more
wiley   +1 more source

Poroelasticity derived from the microstructure for intrinsically incompressible constituents. [PDF]

Z Angew Math Phys
Penta R, Lonati C, Miller L, Marzocchi A.   +3 more
europepmc   +1 more source