Results 81 to 90 of about 166,339,283 (190)

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

open access: yesExperimental Physiology, EarlyView.
Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized experimental conditions. Here, we performed a standardized electrophysiological
Rajnish Ranjan   +5 more
wiley   +1 more source

”New Connections between dynamical systems and Hamiltonian PDEs”

open access: yes, 2010
This is a course of 8 hours on Hamiltonian PDEs: main examples, Nash-Moser IFT, tame estimates of the inverse linearzied operator, application to NLS and ...
BERTI, MASSIMILIANO
core  

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

Utility of local capillary supply indices: Insights from computational image‐based modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Local capillary distribution and fibre geometry influence oxygen availability in skeletal muscle. Image‐based modelling of tissue PO2${{P}_{{{{\mathrm{O}}}_2}}}$ shows that area‐based measures of capillary supply – the local capillary density (LCDi) and local maximum diffusion distance (Dmax,i) – most accurately represent the ...
Abdullah A. Al‐Shammari   +6 more
wiley   +1 more source

Subspace Acceleration for Efficient Nonlinear Water Wave Simulation

open access: yesInternational Journal for Numerical Methods in Fluids, Volume 98, Issue 10, Page 1165-1180, October 2026.
We introduce an exponentially weighted subspace acceleration technique to reduce GMRES iterations for solving the Poisson equation with time‐dependent coefficients in nonlinear, dispersive free‐surface flows governed by the incompressible Navier‐Stokes equations. The method significantly reduces memory requirements and computational complexity compared
Rasmus Kleist Hørlyck Sørensen   +3 more
wiley   +1 more source

Indirect RBFN method with scattered points for numerical solution of PDEs [PDF]

open access: yes, 2004
This paper is concerned with the use of the indirect radial basis function network (RBFN) method in solving partial differential equations (PDEs) with scattered points.
Mai-Duy, Nam
core   +1 more source

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

open access: yesMedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes

open access: yesActa Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi   +8 more
wiley   +1 more source

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman   +3 more
wiley   +1 more source

Random Carbon Tax Policy and Investment Into Emission Abatement Technologies

open access: yesMathematical Finance, Volume 36, Issue 4, Page 804-825, October 2026.
ABSTRACT We analyze the problem of a profit‐maximizing electricity producer, subject to carbon taxes, who decides on investments into CO2$\rm CO_2$ abatement technologies. We assume that the carbon tax policy is random and that the investment in the abatement technology is divisible, irreversible, and subject to transaction costs.
Katia Colaneri   +2 more
wiley   +1 more source

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