Results 41 to 50 of about 190,595 (336)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

LA LIBERTAD RELIGIOSA EN ESPAÑA Y LA IRRUPCIÓN DE NUEVOS MOVIMIENTOS SOCIALES RELIGIOSOS

open access: yesRevista Internacional de Pensamiento Político, 2018
En este trabajo realizamos una breve exposición de las cuestiones históricas, políticas y legales que han influido en el desenvolvimiento de nuevos movimientos sociales religiosos en nuestro país.
Rocío de Diego Cordero
doaj   +2 more sources

Correlation of Psoriasis Disability Index and Psoriasis Area and Severity Index: A Study from Afghanistan

open access: yesClinical, Cosmetic and Investigational Dermatology, 2022
Ahmad Khalid Aalemi,1,2 Abdul Ghafar Hamdard,2 Ahmad Shekeb Sobat3 1Department of Oral Medicine, Kabul University of Medical Sciences, Kabul, 1001, Afghanistan; 2Department of Dermatology, Maiwand Teaching Hospital, Kabul University of Medical Sciences ...
Aalemi AK, Hamdard AG, Sobat AS
doaj  

Protein disulphide isomerase inhibition as a potential cancer therapeutic strategy

open access: yesCancer Medicine, 2021
The protein disulphide isomerase (PDI) gene family is a large, diverse group of enzymes recognised for their roles in disulphide bond formation within the endoplasmic reticulum (ER).
Lauren E. Powell, Paul A. Foster
doaj   +1 more source

Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. [PDF]

open access: yes, 2008
Sulfatase modifying factor 1 (SUMF1) encodes for the formylglicine generating enzyme, which activates sulfatases by modifying a key cysteine residue within their catalytic domains. SUMF1 is mutated in patients affected by multiple sulfatase deficiency, a
Annunziata F.   +10 more
core   +1 more source

Intermolecular Interactions as Driving Force of Increasing Multiphoton Absorption in a Perylene Diimide‐Based Coordination Polymer

open access: yesAdvanced Functional Materials, EarlyView.
This study uncovers the unexplored role of intermolecular interactions in multiphoton absorption in coordination polymers. By analyzing [Zn2tpda(DMA)2(DMF)0.3], it shows how the electronic coupling of the chromophores and confinement in the MOF enhance two‐and three‐photon absorption.
Simon Nicolas Deger   +11 more
wiley   +1 more source

Effect of Different Substitutions at the 1,7-Bay Positions of Perylenediimide Dyes on Their Optical and Laser Properties

open access: yesMolecules, 2023
Perylenediimide (PDI) compounds are widely used as the active units of thin-film organic lasers. Lately, PDIs bearing two sterically hindering diphenylphenoxy groups at the 1,7-bay positions have received attention because they provide a way to red-shift
Nathalie Zink-Lorre   +8 more
doaj   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

open access: yesAdvanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li   +6 more
wiley   +1 more source

Preparation, purification and characterization of aminopropyl-functionalized silica sol [PDF]

open access: yes, 2013
A new, simple and “green” method was developed for the surface modification of 20 nm diameter Stöber silica particles with 3-aminopropyl(diethoxy)methylsilane in ethanol. The bulk polycondensation of the reagent was inhibited and the stability of the sol
Attila Bóta   +47 more
core   +1 more source

Speckle‐Engineered Upconversion Amplification in Nanoemulsion‐Templated Hydrogel Microdomes

open access: yesAdvanced Functional Materials, EarlyView.
Nanoemulsion‐confined PEGDA microdomes generate speckle‐like excitation fields that strongly amplify upconversion luminescence upon dehydration, enabling filter‐free visible readout with reversible on–off switching. DMD‐based lithography yields scalable, shape‐programmable arrays for moisture‐responsive displays and optical encryption.
Chaeyeong Ryu   +13 more
wiley   +1 more source

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