Results 81 to 90 of about 5,888,395 (293)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Peak statistics on COBE maps [PDF]

, 1995
We perform the stastistics of temperature maxima and minima in COBE-DMR 2-year maps. For power-law spectra the surface distribution of peaks implies an amplitude consistent with more conventional analyses of COBE data (for instance, we get $Q_{{\rm rms ...
Fabbri, R., Torres, S.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

X-ray Flux and Spectral Variability of Blazar H 2356-309

Galaxies, 2020
We present the results of timing and spectral analysis of the blazar H 2356-309 using XMM-Newton observations. This blazar is observed during 13 June 2005–24 December 2013 in total nine observations.
Kiran A. Wani, Haritma Gaur
doaj   +1 more source

Precritical calculations for the 2.9 in. pitch, twmr critical assembly [PDF]

Critical loadings and precritical calculations for 2.9 inch pitch core in determining feasibility of isotopically enriched tungsten water moderated reactor for use as nuclear ...
Lovallo, J. M., Peak, J. C.
core   +1 more source

Peak reduction technique in commutative algebra

, 1999
The "peak reduction" method is a powerful combinatorial technique with applications in many different areas of mathematics as well as theoretical computer science.
D Wright, H Nagao, IR Shafarevich, J Mckay, M Suzuki, M.G.Zaidenberg, M.G., Lin, V.Ya, PM Cohn, R Lyndon, SS Abhyankar, V Shpilrain, W Adams, W Dicks   +11 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Magnetic resonance peak and nonmagnetic impurities

, 2000
Nonmagnetic Zn impurities are known to strongly suppress superconductivity. We review their effects on the spin excitation spectrum in $\rm YBa_2Cu_3O_{7}$, as investigated by inelastic neutron scattering measurements.Comment: Proceedings of Mato ...
AV Balatsky, AV Balatsky, B Nachumi, C Bernhard, D Morr, D Poilblanc, D Poilblanc, DA Bernhard, H Kim, HA Mook, HA Mook, HF Fong, HF Fong, HF Fong, HF Fong, HF Fong, J Riera, J Rossat-Mignod, JX Li, K Ishida, LP Regnault, LP Regnault, LS Borkowski, M Arai, M Franz, M Tarascon, M Vojta, P Bourges, P Bourges, P Bourges, P Bourges, P Dai, P Dai, P Mendels, R Fehrenbacher, S Odashima, SH Pan, T Hotta, VA Mahajan, W Ziegler, Y Ohta, Y Sidis, Y Sidis, Y Sidis, Y Sun   +44 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source