Results 41 to 50 of about 26,422 (301)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Probabilistic seismic hazard assessment in Greece – Part 1: Engineering ground motion parameters [PDF]

Natural Hazards and Earth System Sciences, 2010
Seismic hazard assessment represents a basic tool for rational planning and designing in seismic prone areas. In the present study, a probabilistic seismic hazard assessment in terms of peak ground acceleration, peak ground velocity, Arias intensity and ...
G-A. Tselentis, L. Danciu
doaj  

Application of metaheuristic algorithms in prediction of earthquake peak ground acceleration

The Journal of Engineering, 2023
The seismic resilience of a structure has been evaluated using peak ground acceleration (PGA). Ground motion parameters such as source characteristics, local site conditions are used to forecast the PGA of the ground motion. This paper aims to develop an
Surya Prakash Challagulla, Ashok Kumar Suluguru, Ehsan Noroozinejad Farsangi, Mounika Manne   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Microzonation Analysis of Cohesionless and Cohesive Soil

MATEC Web of Conferences, 2017
Urban seismic risk is a continuous worldwide issue, numerous researchers are putting great effort in dealing with how to minimise the level of the threat.
Tan Choy Soon, Koh Yong Chang, Marto Aminaton   +2 more
doaj   +1 more source

Adaptability of a jump movement pattern to a non-constant force field elicited via centrifugation.

PLoS ONE, 2020
Humans are accustomed to Earth's constant gravitational acceleration of 1g. Here we assessed if complex movements such as jumps can be adapted to different acceleration levels in a non-constant force field elicited through centrifugation.
Andreas Kramer, Jakob Kümmel, Maren Dreiner, Steffen Willwacher, Timo Frett, Anja Niehoff, Markus Gruber   +6 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Study on the Hydrodynamic Effects of Bridge Piers Under Velocity-Type Pulse Ground Motion Based on Different Characteristic Periods

Applied Sciences
This study was based on a target spectrum (GB183062015) and synthesized different characteristic periods, pulse ground motions, and non-pulse ground motions utilizing EQsignal v1.2.1 software. It also investigated the dynamic behaviors of bridge piers in
Gaojie Yun, Chunguang Liu
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Evaluation of the seismic response of a reinforced concrete footing with stub column to increasing peak ground acceleration using pseudo-dynamic experimentation [PDF]

, 2022
C.P. Roth, Roth, C P
openalex   +1 more source