Results 61 to 70 of about 355,000 (288)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Seismic Modeling with an Earthquake Shake Table [PDF]

, 2012
An earthquake shake table was constructed with three orthogonal directions of motion to simulate seismic waves. The peak amplitude and directions of motion are adjustable by the user.
Barnes, Jordan E
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Spectrum-to-spectrum methods for the generation of elastic floor acceleration spectra [PDF]

, 2017
In seismic codes, the acceleration demand of nonstructural components is commonly expressed in terms of floor response spectra and estimated by means of simple predictive equations.
FRANCHIN, Paolo, LUCCHINI, Andrea, MOLLAIOLI, Fabrizio   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Monte Cristo Range earthquake May 15, 2020: calculated intensity and macroseismic field

Геология и геофизика Юга России, 2022
Relevance. When studying the seismic effect of the occurred earthquake, the collected macroseismic data are of great importance. To design the most reliable map of the macroseismic field, it’s necessary to have the sufficient number of such data, which ...
О.О. Эртелева, Ф.Ф. Аптикаев, К.С.К. Картик Редди, С. Чанда, С.Н. Сомала   +4 more
doaj  

Application of metaheuristic algorithms in prediction of earthquake peak ground acceleration

The Journal of Engineering, 2023
The seismic resilience of a structure has been evaluated using peak ground acceleration (PGA). Ground motion parameters such as source characteristics, local site conditions are used to forecast the PGA of the ground motion. This paper aims to develop an
Surya Prakash Challagulla, Ashok Kumar Suluguru, Ehsan Noroozinejad Farsangi, Mounika Manne   +3 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Probabilistic seismic hazard assessment in Greece – Part 1: Engineering ground motion parameters [PDF]

Natural Hazards and Earth System Sciences, 2010
Seismic hazard assessment represents a basic tool for rational planning and designing in seismic prone areas. In the present study, a probabilistic seismic hazard assessment in terms of peak ground acceleration, peak ground velocity, Arias intensity and ...
G-A. Tselentis, L. Danciu
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source