Results 41 to 50 of about 2,673,001 (287)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Mapping of Two Models Peak Ground Acceleration (PGA) of Indonesia
Journal of Physics: Conference Series, 2021 AbstractThis research was conducted to determine and mapping the value of the PGA in Indonesian territory using two empirical models of attenuation equations from the transition of the second generation to the third generation. The research was conducted by applying the Frisenda’s and Luzi’s.
T Zera +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Additional acceleration of solar-wind particles in current sheets of the heliosphere [PDF]
, 2015 Particles of fast solar wind in the vicinity of the heliospheric current sheet (HCS) or in a front of interplanetary coronal mass ejections (ICMEs) often reveal very peculiar energy or velocity profiles, density distributions with double or triple peaks,
V. Zharkova +4 more
core +2 more sources
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Estimation of Peak Ground Acceleration from Horizontal Rigid Body Displacement: A Case Study in Port-au-Prince, Haiti [PDF]
The Mw7.0 Haiti earthquake of 12 January 2010 caused catastrophic damage and loss of life in the capital city of Port-au-Prince. The extent of the damage was primarily due to poor construction and high population density.
Altidor, Jean-Robert +7 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Monte Cristo Range earthquake May 15, 2020: calculated intensity and macroseismic field
Геология и геофизика Юга России, 2022 Relevance. When studying the seismic effect of the occurred earthquake, the collected macroseismic data are of great importance. To design the most reliable map of the macroseismic field, it’s necessary to have the sufficient number of such data, which ...
О.О. Эртелева +4 more
doaj
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Feasibility of Applying Kriging for Earthquake Ground Motion Intensity Measures in South Korea
Applied SciencesEstimating ground motion parameters at an unsampled site is challenging for seismologists and engineers alike. An attempt is made to apply Kriging interpolation to estimate peak ground accelerations at specific nuclear power plant sites.
Eric Yee, Jung-ho Kim
doaj +1 more source