Results 41 to 50 of about 1,720,158 (289)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

ANALYSIS OF THE IMPACT OF ATTRACTION AND GENERATION ON THE PERFORMANCE OF JALANKAPTEN A. BAKARUDIN, JAMBI CITY

Jurnal Pensil, 2022
One of the supports for the economy in Jambi province is the Shopping Center Development of shopping centers. Jambi Town Square Mall is one of the shopping centers in the City of Jambid with the Jambi Town Square Mall resulting in an additional volume ...
Ade Nurdin, Yanuar Fitri, Nuklirullah Nuklirullah   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of Rainfall Characteristicsfor Flood Estimation in Way Awi Watershed

Civil Engineering Dimension, 2021
This study investigates rainfall intensity distribution in Way Awi watershed located in Bandar Lampung, and how their impacts on flood peak and flood hydrographs.
Dyah I. Kusumastuti, D. Jokowinarno, C.H. Van Rafii, F. Yuniarti   +3 more
doaj  

Temporal Fluctuated Features of Metro Traction Load Current in DC Railway

IEEE Access, 2020
24-hour traction current based on Wuhan Metro Line 6 are reported. The fluctuation features, which corresponding to the interval of vehicle operation, indicate that there are four types of inrush current periodically appearing throughout the all-day ...
Gen Qian, Jianguo Wang, Yadong Fan, Mi Zhou, Mengrong Gong, Wen Chen   +5 more
doaj   +1 more source

Identifying Residential Water End Uses Underpinning Peak Day and Peak Hour Demand [PDF]

Journal of Water Resources Planning and Management, 2014
AbstractAccurate and up-to-date peak demand data are essential to ensure that future mains water supply networks reflect current usage patterns and are designed efficiently from an engineering, environmental, and economic perspective. The aim of this paper was to identify the water end-uses that drive peak day demand and to examine their associated ...
Beal, Cara D, Stewart, Rodney A
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Traffic congestion analysis using travel time ratio and degree of saturation on road sections in Palembang, Bandung, Yogyakarta, and Surakarta

MATEC Web of Conferences, 2018
Traffic performance have been measured based on degree of saturation, velocity, travel time, and delays. However, they weren’t enough to measure the traffic fluctuation that happen on normal days.
Hartanto Susilo Budi, Imanuel Ivan
doaj   +1 more source

Optimizing the Over and Underutilization of Network Resources During Peak and Off-Peak Hours

IEEE Access
In 2022, the digital population reached 5.4 billion, leading to network congestion, primarily attributed to the widespread use of social media, robotic programs, and prime-time television during peak hours. This congestion posed a significant challenge, as sensitive services struggled to operate effectively during peak hours, while network resources ...
Afzal Badshah, Ali Daud, Hikmat Ullah Khan, Omar Alghushairy, Amal Bukhari   +4 more
openaire   +3 more sources