Results 41 to 50 of about 312,594 (254)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Analysis of Rainfall Characteristicsfor Flood Estimation in Way Awi Watershed
Civil Engineering Dimension, 2021 This study investigates rainfall intensity distribution in Way Awi watershed located in Bandar Lampung, and how their impacts on flood peak and flood hydrographs.
Dyah I. Kusumastuti +3 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Temporal Fluctuated Features of Metro Traction Load Current in DC Railway
IEEE Access, 2020 24-hour traction current based on Wuhan Metro Line 6 are reported. The fluctuation features, which corresponding to the interval of vehicle operation, indicate that there are four types of inrush current periodically appearing throughout the all-day ...
Gen Qian +5 more
doaj +1 more source
Optimizing the Over and Underutilization of Network Resources During Peak and Off-Peak Hours
IEEE AccessIn 2022, the digital population reached 5.4 billion, leading to network congestion, primarily attributed to the widespread use of social media, robotic programs, and prime-time television during peak hours. This congestion posed a significant challenge, as sensitive services struggled to operate effectively during peak hours, while network resources ...
Afzal Badshah +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MATEC Web of Conferences, 2018 Traffic performance have been measured based on degree of saturation, velocity, travel time, and delays. However, they weren’t enough to measure the traffic fluctuation that happen on normal days.
Hartanto Susilo Budi, Imanuel Ivan
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
GIS APPLICATION TO EVALUATE TRANSPORTATIONS NETWORK IN NASIRIYAH CITY
Journal of Engineering and Sustainable Development, 2017 Transportation is an essential element for the development of countries economically, socially, and culturally, where the progress in countries is measured through the progress in transportation systems and urban road networks.
Abdul-Razzak T. Ziboon +2 more
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