Results 51 to 60 of about 1,720,158 (289)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Peak-Hour Caching Schemes of Mobile Devices for Overload Cells in Wireless Caching Systems

IEEE Access, 2020
In the case of broadband wireless communication systems with high carrier frequencies, high-speed wireless communication is feasible, but if high-capacity backhaul is not supplied to all base stations, a backhaul bottleneck may occur.
Minjoong Rim, Chung G. Kang
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Temporal instability of highway pedestrian crash severity: Comparative analysis of machine learning models

Transportation Research Interdisciplinary Perspectives
Globally, pedestrian-involved crashes on national highways are considered unacceptable due to the clearly defined functional hierarchy of roadways. This study utilizes advanced machine learning (ML) techniques to investigate the severity of pedestrian ...
Panuwat Wisutwattanasak, Chamroeun Se, Sonita Sum, Thanapong Champahom, Vatanavongs Ratanavaraha, Sajjakaj Jomnonkwao   +5 more
doaj   +1 more source

Predicting Station-level Peak Hour Ridership of Metro Considering the Peak Deviation Coefficient

, 2023
Abstract Subway station-level peak hour ridership (SPR) is a crucial input parameter for multiple applications, including the planning, design, construction, and operation of stations. However, traditional SPR estimation techniques may produce biased results.
Lijie Yu, Jie We
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

GIS APPLICATION TO EVALUATE TRANSPORTATIONS NETWORK IN NASIRIYAH CITY

Journal of Engineering and Sustainable Development, 2017
Transportation is an essential element for the development of countries economically, socially, and culturally, where the progress in countries is measured through the progress in transportation systems and urban road networks.
Abdul-Razzak T. Ziboon, Zaynab I. Qasim, Khaldoon T. Falih   +2 more
doaj  

Comparative Evaluation of the Laboratory Efficiency before and after Total Lab Automation in Tertiary Care Hospital Laboratory in Pakistan

Pakistan Journal of Medical Research, 2023
Background: Advance technology and diagnostic approach to disease has increased workload burden on laboratory and timely reporting as well as reliable results provision to physicians is another challenge of laboratory.Objective ...
Ghazanfar Abbas, Qurat ul ain, Imran Nazir Ahmed, Naveed Asif, Waqas Hanif   +4 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Generación de electricidad en horas de punta a partir de la digestión anaeróbica de camalote

Ingeniería e Investigación, 2011
El presente trabajo tiene como objeto de presentar una propuesta novedosa y sustentable para la generación de energía eléctrica en el área metropolitana de Asunción basada en una fuente renovable de energía.
A. Maioli, J. Pulfer, F. Mitjans
doaj