Results 71 to 80 of about 312,594 (254)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

On the safety effects of off-peak hour speed characteristics of urban arterials

Multimodal Transportation
Among the factors related to traffic crash risk, the speed characteristics are crucial. Most studies on the safety effect of speed characteristics focused on highways and rural roads, whereas the investigations on urban roads are not comprehensive. Urban
Sixuan Xu, Xinbo Xie, Chen Wang, Junyi Yan   +3 more
doaj   +1 more source

Time Headway Modelling of Motorcycle-Dominated Traffic to Analyse Traffic Safety Performance and Road Link Capacity of Single Carriageways

Jurnal Teknik Sipil, 2017
This study aims to develop time headway distribution models to analyse traffic safety performance and road link capacities for motorcycle-dominated traffic in Denpasar, Bali. Three road links selected as the case study are Jl.
D. M. Priyantha Wedagama
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Analysis of Rainfall Characteristicsfor Flood Estimation in Way Awi Watershed

Civil Engineering Dimension, 2016
This study investigates rainfall intensity distribution in Way Awi watershed located in Bandar Lampung, and how their impacts on flood peak and flood hydrographs. Hourly rainfall data is examined to obtain design rainfall intensity and rainfall intensity
Kusumastuti D.I., Jokowinarno D., van Rafi’i C.H., Yuniarti F.   +3 more
doaj  

Comparison of Flood Hydrograph of Manikin Dam Watershed Using Synthetic Unit Hydrograph Method, HEC-HMS and Rain on Grid Model with HEC-RAS 2D

Journal of Civil Engineering
Manikin watershed is located in Kuaklalo Village which borders Bokong Village, Taebenu Subdistrict, Kupang Regency, East Nusa Tenggara Province which has an area of 49.31 km2 with a river length of 8.62 km which has a semi-arid climate with a fairly ...
Mariano Ado Galot Pukan, Umboro Lasminto
doaj   +1 more source

Sex differences in 24-hour ultra-marathon performance - A retrospective data analysis from 1977 to 2012

Clinics, 2014
OBJECTIVES: This study examined the changes in running performance and the sex differences between women and men in 24-hour ultra-marathons held worldwide from 1977 to 2012.
Laura Peter, Christoph Alexander Rust, Beat Knechtle, Thomas Rosemann, Romuald Lepers   +4 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source