Results 81 to 90 of about 1,720,158 (289)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Sex differences in 24-hour ultra-marathon performance - A retrospective data analysis from 1977 to 2012

Clinics, 2014
OBJECTIVES: This study examined the changes in running performance and the sex differences between women and men in 24-hour ultra-marathons held worldwide from 1977 to 2012.
Laura Peter, Christoph Alexander Rust, Beat Knechtle, Thomas Rosemann, Romuald Lepers   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

On the safety effects of off-peak hour speed characteristics of urban arterials

Multimodal Transportation
Among the factors related to traffic crash risk, the speed characteristics are crucial. Most studies on the safety effect of speed characteristics focused on highways and rural roads, whereas the investigations on urban roads are not comprehensive. Urban
Sixuan Xu, Xinbo Xie, Chen Wang, Junyi Yan   +3 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Analysis of Rainfall Characteristicsfor Flood Estimation in Way Awi Watershed

Civil Engineering Dimension, 2016
This study investigates rainfall intensity distribution in Way Awi watershed located in Bandar Lampung, and how their impacts on flood peak and flood hydrographs. Hourly rainfall data is examined to obtain design rainfall intensity and rainfall intensity
Kusumastuti D.I., Jokowinarno D., van Rafi’i C.H., Yuniarti F.   +3 more
doaj  

Comparison of 24-Hour Intraocular Pressure Profiles in Medically Controlled Open Angle Glaucoma Versus Surgically Managed Open Angle Glaucoma: A Case Series

TNOA Journal of Ophthalmic Science and Research
Intraocular pressure (IOP) reduction continues to be the mainstay of glaucoma treatment. IOP fluctuations increase the risk of progression. In patients with well controlled office hours IOPs, very few studies have compared the effectiveness of surgical ...
S Jenifer Jeevakumari, Roshni Jegan, Serin Mariam Sajan, Reka Karrupusami, Arathi Simha, Lekha M. Abraham   +5 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Idle Hour Theatre Movie Schedule

, 2020
Movies featured at the Idle Hour Theatre in Rochester, Michigan.
Idle Hour Theatre
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