Results 121 to 130 of about 38,415 (297)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Vehicle-to-Grid - What is the Benefit for a Sustainable Mobility? [PDF]

The demand for vehicles in industrialised countries is dropping and the growth rate in developing countries is slowing down rapidly. Driver of this evolution is evidently the current crisis but also the expectation that in the long run oil will not be ...
Guy Fournier, Michael Terporten, Stefan Haugrund   +2 more
core  

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

A comprehensive optimization method for peak shaving performance of combined cycle steam heating units

Frontiers in Energy Research
IntroductionThe rapid expansion of wind and photovoltaic power has intensified the demand for deep peak shaving in coal-fired power units. Conventional extraction steam heating units are constrained by thermal–electric coupling, limiting their ability to
Libin Wen, Libin Wen, Zhiyuan Sun, Zhiyuan Sun, Hong Hu, Hong Hu, Jinji Xi, Jinji Xi   +7 more
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Energy storage configuration considering user-shared costs in peak shaving auxiliary services with improved multi-objective particle swarm optimization

AIP Advances
To enhance peak-shaving and valley-filling performance in residential microgrids while reducing the costs associated with energy storage systems, this paper selects retired power batteries as the storage solution, breaking through existing optimization ...
Yiyou Xing, Jin Shen, Xinru Li
doaj   +1 more source

Application and Economic Study on Deep Peak Shaving System for Coal-Fired Units Coupled with Non-Supplementary Compressed Air Energy Storage Technology

南方能源建设
[Objective] To enhance the deep peak shaving capacity of coal-fired units, this paper proposes a deep peak shaving system for coal-fired units coupled with non-supplementary compressed air energy storage.
Ting XU, Jingzheng HOU, Yuzhang ZHU, Chengwei LIU, Zhide ZHU, Yuchu LIU   +5 more
doaj   +1 more source

Assessment of the potential of solar thermal small power systems in small utilities [PDF]

The potential economic benefit of small solar thermal electric power systems to small municipal and rural electric utilities is assessed. Five different solar thermal small power system configurations were considered in three different solar thermal ...
Mayo, L. G., Perkins, S. P., Jr., Steitz, P.   +2 more
core   +1 more source