Results 181 to 190 of about 9,760 (263)

First molecular insight into <i>Ovar-DRB1</i> exon 2 in Edilbay sheep: High heterozygosity and detection of novel variants. [PDF]

Vet World
Marzanova SN, Devrishov DA, Zuchkov VA, Marzanov NS, Nikolaeva EA.   +4 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Lev Tolstoy, A Founder of Democratic Education. [PDF]

Integr Psychol Behav Sci
Matusov E.
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Willingness to pay for combined medical and old-age care services: A survey in Chengdu City, China. [PDF]

Medicine (Baltimore)
Guo CR, Lu YG, Zhu H, Zhao Y.
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Divine thus good, devilish thus bad? Folk linguistic perceptions about plants and their characteristics in Polish folklore. [PDF]

J Ethnobiol Ethnomed
Kielak O.
europepmc   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Characterisation of harmful use of alcohol in a rural setting: A Pilot study around Lake Bunyonyi in Kigezi Sub-region, Uganda

Tumwesigye NM, Mubangizi V, Karugahe W, Napyo A, Maling S, Mukose A, Gitige C, Mbuo M, Namanda C, Willcox M.   +9 more
europepmc   +1 more source

Changes of beneficiaries after Red Cross safe motherhood project in Northern Uganda. [PDF]

Afr Health Sci
Ogata A, Naiki M, Saito Y, Onzima A.
europepmc   +1 more source