Results 191 to 200 of about 9,760 (263)

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Exploring the lived experiences of pregnant and breastfeeding teenage mothers in the conflict and post conflict Acholi sub Region, Uganda. [PDF]

Afr Health Sci
Odoch FA, Damulira C, Frank KP, Robert WO, Twimukye A.   +4 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Explaining mobilization for revolts by private interests and kinship relations. A response to the comment by Nieva. [PDF]

Ration Soc
Armandola NG, Doehne M, Rost K.
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Prevalence and factors associated with mental health challenges among adolescents with HIV and viral non-suppression in rural northern Uganda. [PDF]

Front Public Health
Kwesiga JM, Namuli JD, Akimana B, Serunjogi JN, Kitaka SB, Seggane M, Kaleebu P, Nyirenda M, Nakimuli-Mpungu E.   +8 more
europepmc   +1 more source

The Peasant

Latin American Research Review, 1978
openaire   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Pre-Exposure Prophylaxis Awareness and Demand Creation: Overlooked Populations and Opportunities to Move Forward. [PDF]

J Acquir Immune Defic Syndr
McCoy K, Mantell JE, Deiss R, Liu A, Bauman LJ, Bonner CP, Vinson J, Buchbinder S.   +7 more
europepmc   +1 more source

Factors associated with modern contraceptive utilization among postpartum adolescent girls and young women in rural Mara, Tanzania: facility-based cross-sectional study. [PDF]

Ther Adv Reprod Health
Sichalwe MM, Tavengana G, Behera MR, Haq FU, Egbobe JO, Ullah S, Kimaro RR, Basit A.   +7 more
europepmc   +1 more source