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Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice

Aging Cell, Volume 25, Issue 8, August 2026.
Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez +11 more
wiley +1 more source

Epidemiological survey on urinary incontinence in school population in Verona (Italy)

La Pediatria Medica e Chirurgica, 2012
The authors tried to estimate the prevalence of urinary incontinence in children between 6 and 13/14 years by administering an anonymous questionnaire to students of primary and secondary 1° schools of the City of Verona.
D. Benini +4 more
doaj +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
Torsten Zuberbier +221 more
wiley +1 more source

Evolution of Neurological Complications in Spine Deformities Surgery in Children

Global Spine Journal, 2015
Study Design This study is a retrospective descriptive study, and Evidence Level IV. Objective This study aims to assess the evolution of neurological complications because of kyphosis or scoliosis surgery in children.
Miguel Angel Godoy +6 more
doaj +1 more source

Escherichia coli causing bloodstream infections in Mexican paediatric patients: molecular typing, antimicrobial resistance, virulence factors, and clinical features

BMC Infectious Diseases
Background Escherichia coli is one of the main pathogens causing bloodstream infections (BSIs) in paediatric patients. It is classified into pathogenic (B2, D and F) and commensal (A, B1 and C) phylogroups, with virulence mainly attributed to adhesins ...
Laura Belmont-Monroy +7 more
doaj +1 more source

Clinical Characterization of Patients With 5q Spinal Muscular Atrophy Types 2 and 3 in Brazil: A Cross‐Sectional Observational Study

Clinical Genetics, Volume 110, Issue 2, Page 172-188, August 2026.
This study describes the clinical heterogeneity of Brazilian patients with 5q spinal muscular atrophy types 2 and 3, highlighting prolonged diagnostic delays and the impact of disease duration on motor function. Early genetic diagnosis and access to multidisciplinary care are crucial to preserve functional outcomes.
Elice Carneiro Batista +31 more
wiley +1 more source

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, Volume 100, Issue 1, Page 154-170, July 2026.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral +52 more
wiley +1 more source

Perturbação de Hiperatividade e Défice de Atenção em Idade Pediátrica: Papel dos Cuidados de Saúde Primários

Gazeta Médica, 2018
A perturbação de hiperatividade/défice de atenção (PHDA) é uma das perturbações do desenvolvimento mais fre-quentes em idade pediátrica. Caracteriza-se por manifestações comportamentais que afetam o funcionamento e de-senvolvimento da criança/adolescente,
Maria Inês Marques +5 more
doaj +1 more source

TINHA CORPORIS – DIAGNÓSTICO NA URGÊNCIA PEDIÁTRICA

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2014
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Virgínia Machado, Hugo Faria, Nádia Pereira +2 more
doaj +1 more source

Bases para el diagnóstico precoz del hipotiroidismo infantil

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2018
CONCLUSIONES I. El examen clínico cuidadoso es primordial para el diagnóstico precoz del hipotiroidismo. II. El retardo en el desarrollo somático, junto con el aumento de la relación P. C./P. P.
Enrique Duplat Yáñez
doaj +1 more source

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