Results 101 to 110 of about 683,288 (212)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Natural excretion of a metallic susceptor originating from an ingested heated tobacco stick

Clinical Case Reports
Key Clinical Message Clinicians should not only consider the presence of metallic foreign bodies within the digestive tract but also contemplate the possibility of nicotine poisoning during the diagnostic process. Abstract When clinicians encounter cases
Hirohito Doi, Toshihiko Kakiuchi, Masafumi Nishino, Masato Yoshiura   +3 more
doaj   +1 more source

Pediatric Patients with Osteomyelitis and/or Septic Joint Undergoing Surgical Debridement Have Equivalent Short-Term Outcomes with or without Preoperative MRI

Children
The purpose of this study was to determine if short-term outcomes differed for pediatric patients with suspected musculoskeletal infection with or without a preoperative MRI.
E. Graham Englert, Collin L. Braithwaite, Maria E. Aguirre-Flores, Aaron W. Lam, Mohamed Sarraj, Abigail Kumagai, E. Dimitra Bednar, Adam M. Gordon, Ibrahim Salama, Jacob Keeley, Indu Pathak, Waleed Kishta, Ahmed M. Thabet, Amr Abdelgawad, Ehab Saleh   +14 more
doaj   +1 more source

Management of Pediatric Nonepileptic Seizures

, 2007
The neurologist’s and child psychiatrist’s perspectives of the diagnosis and treatment of pediatric nonepileptic seizures (NES) were discussed at a multidisciplinary workshop sponsored by the National Institutes of Neurological Disorders and Stroke and ...
J Gordon Millichap, Millichap, J. Gordon
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Wheelchair Dance: Exploring a Novel Approach to Enhance Wheelchair Skills, Belongingness and Inclusion among Children with Mobility Limitations

Disabilities
Playful approaches are recommended to enhance wheelchair skills training with young people. Inclusive dance allows participants to discover motor skills and improve social participation.
Jade Berthiaume, Claire Cherriere, Béatrice Ouellet, Laurence Éthier, Paula W. Rushton, Martin Lemay, Krista L. Best   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Abstracts of the 2nd International Congress of Contemporary Pediatric Dentistry (ICCPD 2022)

Contemporary Pediatric Dentistry, 2022
Contemporary Pediatric Dentistry
doaj   +1 more source

Pediatric-onset inflammatory brain diseases to be included in the Swiss Pediatric Inflammatory Brain Disease Registry.

Pediatric-onset inflammatory brain diseases to be included in the Swiss Pediatric Inflammatory Brain Disease Registry.
Claudia Elisabeth Kuehni (7582928), Lorena Freya Hulliger (18389093), Anne Tscherter (18389096), Sandra Bigi (12625589)   +3 more
core   +1 more source