Results 31 to 40 of about 877,343 (248)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Pediatricians perception of stool color cards as a screening tool for biliary atresia: a cross-sectional survey in Sudan

Alexandria Journal of Medicine
Background A stool color card has improved the prognosis of biliary atresia patients since it was first developed in Japan. This study investigated how Sudanese pediatric residents currently utilize stool color cards.Methods In January and February of ...
Rayan Sharief Shaibo, Muaath Ahmed Mohammed, Hanaa Ahmed Hamad   +2 more
doaj   +1 more source

Fecal calprotectin levels in Helicobacter pylori gastritis in children

The Turkish Journal of Pediatrics, 2020
Background. Fecal calprotectin is an important inflammatory marker in intestinal diseases and is not routinely used in the upper gastrointestinal system disorders.
Özlem Yüksel Aksoy, Oğuz Canan, Ferda Özbay Hoşnut, EdaYılmaz Akçay, Figen Özçay   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Daytime variation of in-hospital mortality and low cardiac output syndrome after pediatric cardiac surgery-a retrospective cohort study

Annals of Medicine
Objective Recent studies suggest that adult cardiac surgery performed in the morning increases the risk of major adverse cardiac events, but it is unclear whether this association exists in pediatric cardiac surgery. This study aimed to determine whether
Chaoyang Tong, Xinwei Du, Kan Zhang, Mengqin Shan, Haibo Zhang, Jijian Zheng   +5 more
doaj   +1 more source

Anxiety Disorders in Pediatric Dentistry and Their Accordance with Parents’ Reports [PDF]

Journal of Health Sciences and Surveillance System
Background: Recent evidence suggests that mental health is associated with dentistry. The aim of the current research was to probe different types of anxiety disorders and phobias in accordance with new changes in the Diagnostic and Statistical Manual of
Esmail Soltani, Najmeh Mohammadi, Ali Sahraian, Lida Vaziri   +3 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Fetal and Early-Life Antibiotics and Risk of Pediatric Inflammatory Bowel Disease: A Population-Based Nationwide Register Study

Journal of Pediatrics: Clinical Practice
Objective: To assess whether antibiotic exposure prenatally and before 2 years of age is associated with subsequent pediatric inflammatory bowel disease (PIBD), as earlier studies diverge substantially in risk estimations or do not include prenatal ...
Svend Andersen, MD, Sigrid Valen Hestetun, MD, Tomm Bernklev, DrPhilos, Gøri Perminow, PhD, Ketil Størdal, PhD   +4 more
doaj   +1 more source

Non-syndromic oropharyngeal hamartoma: A case report [PDF]

Romanian Medical Journal
This case report details the presentation, investigation, management, and histopathological examination of a rare occurrence – non-syndromic oropharyngeal hamartomas in a 2-year-old child.
Kanwar Vikrant Singh, Gurpreet Singh, Surabhi Gupta, Paromita Patra   +3 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source