Results 141 to 150 of about 60,403 (253)

Commentary: “PCRRT Expert Committee ICONIC Position Paper on Prescribing Kidney Replacement Therapy in Critically Sick Children With Acute Liver Failure”

Frontiers in Pediatrics, 2022
Akash Deep, Akash Deep, Emma C. Alexander, Emma C. Alexander, Zaccaria Ricci, Serge Grazioli, Claudio Ronco, Stuart Goldstein, Ayse Akcan-Arikan, Ayse Akcan-Arikan   +9 more
doaj   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Pediatric liver transplantation. Part II. Diagnostic imaging in postoperative management [PDF]

, 1985
Bron, KM, Cienfuegos, X, Dominguez, K, Gartner, JC, Ledesma-Medina, L, Starzl, TE, Young, LW   +6 more
core   +1 more source

Sudan at War With Itself: Civilian Devastation in the Civil War

Conflict Resolution Quarterly, EarlyView.
ABSTRACT A civil war is raging in Sudan between the Sudan Armed Forces (SAF) and the Rapid Support Forces (RSF) along with militia groups. Beginning on April 15, 2023, and continuing at least to this writing (October 15, 2025), civilian noncombatants have been subjected to bombings, beatings, torture, shootings, rape, and murder on a large scale. Since
Daniel Rothbart, Bayan Abubakr, Beltina Gjeloshi, Dieter Pfoser   +3 more
wiley   +1 more source

Dissecting the Influence of Batch Effects on Immunomics Pattern Discovery in High‐Dimensional Mass Cytometry

Cytometry Part A, EarlyView.
ABSTRACT High‐dimensional cytometry, such as mass cytometry (CyTOF), measures protein expression in single cells. When paired with AI‐enhanced data analytics, it facilitates the discovery of immune biomarkers that can assist in diagnosing and treating immune‐related diseases. However, fluctuating instrument readouts, known as batch effects, can obscure
Martin Wasser, Joo Guan Yeo, Valerie Chew, Jing Yao Leong, Salvatore Albani   +4 more
wiley   +1 more source

NEPHROTOXICITY OF CYCLOSPORINE IN LIVER-TRANSPLANTATION [PDF]

, 1984
ESQUIVEL, CO, GORDON, RD, IWATSUKI, S, KLINTMALM, GBG, SHAW, BW, STARZL, TE   +5 more
core  

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source