Results 201 to 210 of about 51,145 (242)

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Interdisciplinary Medicine, EarlyView.
This comprehensive review highlights the transformative role of 3D printing and bioprinting technologies in the regeneration of female reproductive organs and the treatment of gynecological diseases. Unlike previous overviews that focus narrowly on isolated applications, this work provides an integrative analysis of recent clinical and preclinical ...
Chan Hum Park, In‐Sun Hong
wiley   +1 more source

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Pediatric Acute Liver Failure and Immune Dysregulation

Journal of Pediatrics, 2014
Apreviously healthy 2-year-old girl was taken to a communityhospitalwith anacuteonsetof jaundice overa several-day period. Her initial exam was remarkable for mild hepatomegaly. There was no splenomegaly or history of fever. Screening laboratory tests revealed elevated aminotransferase levels, conjugated hyperbilirubinemia, and thrombocytopenia.
John Bucuvalas, Michael Grimley, Frank Dipaola   +2 more
exaly   +3 more sources

Improved outcomes in pediatric liver transplantation for acute liver failure

Pediatric Transplantation, 2010
Miloh T, Kerkar N, Parkar S, Emre S, Annunziato R, Mendez C, Arnon R, Suchy F, Rodriguez‐Laiz G, Del Rio Martin J, Sturdevant M, Iyer K. Improved outcomes in pediatric liver transplantation for acute liver failure.
Pediatr Transplantation 2010: 14:863–869. © 2010 John Wiley & Sons A/S.Abstract:  OLT is a life‐saving option for ALF. Aim: To evaluate
Rachel Annunziato, Gonzalo P Rodrıguez Laiz, Nanda Kerkar   +2 more
exaly   +3 more sources

Live donor liver transplantation for pediatric acute liver failure: challenges and outcomes

Hepatology International, 2023
This study aimed at studying the challenges and outcomes of live-donor liver transplantation (LDLT) for pediatric acute liver failure (PALF).A total of 315 patients with PALF were treated over a period of 11 years. 42 underwent LT (41 LDLT and one DDLT), constituting 38% (41/110) of all pediatric transplants during this duration.
Bikrant Bihari Lal, Viniyendra Pamecha, Nilesh Sadashiv Patil   +2 more
exaly   +3 more sources

Pediatric acute liver failure: variations in referral timing are associated with disease subtypes

European Journal of Pediatrics, 2014
In pediatric acute liver failure (PALF), rapid referral to a transplant center (TC) is advocated. Clinical variability of PALF may influence referral timing. We aimed to analyze early or late timing of referral in relation to clinical characteristics and outcome in PALF.
Ekkehard Sturm, Henkjan J Verkade
exaly   +4 more sources

Pediatric acute liver failure: Current perspective in etiology and management

Indian Journal of Gastroenterology
Pediatric acute liver failure (PALF) is a catastrophic clinical condition with very high morbidity and mortality without early detection and intervention. It is characterized by the acute onset of massive hepatocellular injury that releases circulating inflammatory mediators, resulting in metabolic disturbances, coagulopathy, hepatic encephalopathy and
Ujjal Poddar, Arghya Samanta, Poddar Ujjal   +2 more
exaly   +3 more sources

Pediatric Acute Liver Failure

Critical Care Clinics, 2022
Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. Up to 50% of children with acute liver failure will never have an underlying cause found.
Catherine, Larson-Nath, Bernadette, Vitola   +1 more
openaire   +2 more sources