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Pediatric Acute Liver Failure

Critical Care Clinics, 2022
Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. Up to 50% of children with acute liver failure will never have an underlying cause found.
Catherine, Larson-Nath   +1 more
openaire   +2 more sources

Pediatric Acute-on-Chronic Liver Failure

Indian Journal of Pediatrics, 2023
Acute-on-chronic liver failure (ACLF) is characterized by an acute hepatic insult happening in a patient with underlying cirrhosis with compromised hepatic reserve leading to development of systemic inflammation, sepsis, and organ failure resulting in poor outcome in majority.
Seema Alam, Bikrant Bihari Lal
openaire   +2 more sources

Pediatric Acute Liver Failure: A Clinicopathological Perspective

Pediatric and Developmental Pathology, 2022
Pediatric acute liver failure (PALF) is a life-threatening disorder characterized by acute hepatocellular injury occurring in children without recognized underlying liver disease. The clinicopathologic evaluation of PALF requires a different approach from that in adults.
Juan, Putra   +2 more
openaire   +2 more sources

Pediatric Liver Transplantation for Acute Liver Failure

Transplantation Proceedings, 2007
The only proven therapy for patients unlikely to recover from acute liver failure (ALF) is liver transplantation. Correct diagnosis of these individuals and rapid referral to a transplant center are crucial. We evaluated 12 pediatric patients with ALF who underwent liver transplantation (LT) at our institution during a 3-year period.
H, Karakayali   +5 more
openaire   +2 more sources

Pediatric Acute Liver Failure and Immune Dysregulation

The Journal of Pediatrics, 2014
Apreviously healthy 2-year-old girl was taken to a communityhospitalwith anacuteonsetof jaundice overa several-day period. Her initial exam was remarkable for mild hepatomegaly. There was no splenomegaly or history of fever. Screening laboratory tests revealed elevated aminotransferase levels, conjugated hyperbilirubinemia, and thrombocytopenia.
Frank, DiPaola   +2 more
openaire   +2 more sources

Extracorporeal renal and liver support in pediatric acute liver failure

Pediatric Nephrology, 2020
The liver is the only organ which can regenerate and, thus, potentially negate the need for transplantation in acute liver failure (ALF). Cerebral edema and sepsis are leading causes of mortality in ALF. Both water-soluble and protein-bound toxins have been implicated in pathogenesis of various ALF complications.
Bogdana Sabina, Zoica, Akash, Deep
openaire   +2 more sources

Infectious Complications in Pediatric Acute Liver Failure

Journal of Pediatric Gastroenterology and Nutrition, 2011
ABSTRACTObjectives:Acute liver failure (ALF) is rare in children but carries high mortality. Infectious complications (IC) in adults are an important cause of mortality; however, there are few data in the pediatric population. The aim of the study was to determine the incidence of IC and their effects on the outcome in children with ALF.Materials and ...
Godbole, Gauri   +3 more
openaire   +3 more sources

Prognostic modeling in pediatric acute liver failure

Liver Transplantation, 2016
Liver transplantation (LT) is the only proven treatment for pediatric acute liver failure (PALF). However, over a period of time, spontaneous native liver survival is increasingly reported, making us wonder if we are overtransplanting children with acute liver failure (ALF).
Vandana, Jain, Anil, Dhawan
openaire   +2 more sources

Live donor liver transplantation for pediatric acute liver failure: challenges and outcomes

Hepatology International, 2023
This study aimed at studying the challenges and outcomes of live-donor liver transplantation (LDLT) for pediatric acute liver failure (PALF).A total of 315 patients with PALF were treated over a period of 11 years. 42 underwent LT (41 LDLT and one DDLT), constituting 38% (41/110) of all pediatric transplants during this duration.
Viniyendra Pamecha   +10 more
openaire   +2 more sources

Intensive Care Management of Pediatric Acute Liver Failure

Journal of Pediatric Gastroenterology and Nutrition, 2017
ABSTRACTPediatric acute liver failure is rare but life‐threatening illness that occurs in children without preexisting liver disease. The rarity of the disease, along with its severity and heterogeneity, presents unique clinical challenges to the physicians providing care for pediatric patients with acute liver failure.
Riad, Lutfi   +5 more
openaire   +2 more sources

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