Results 61 to 70 of about 6,439 (185)

Phenotypic Clues in Infantile‐Onset Parkinsonism‐Dystonia‐2: A Treatable Neurotransmitter Disorder

Movement Disorders Clinical Practice, EarlyView.
Sangeetha Yoganathan, Haya S. AlFaris, Lindsey Vogt, Michele Eid, Anika Menetrey, Sayoni Roy Chowdhury, Dawn Codeiro, Pradeep Krishnan, Liali Aljouda, Emily W.Y. Tam, Carolina Gorodetsky   +10 more
wiley   +1 more source

Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population

Allergy, EarlyView.
The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard, Ralph Heijmans, Virgil A. S. H. Dalm, Silvan Licher, Jan Nouta, Steinar Gijze, David Falck, P. Martin van Hagen, Robin Peeters, Manfred Wuhrer, Layal Chaker   +10 more
wiley   +1 more source

A Systematic Review on the Presentation and Management of Segmental Testicular Infarction

Andrology, EarlyView.
ABSTRACT Background Segmental testicular infarction (STI) is a rare and likely underdiagnosed cause of acute scrotal pain. Its clinical and imaging presentation often mimics testicular torsion or malignancy, frequently leading to unnecessary surgical intervention.
Lory Hage, Alexandra Clerget, Aziz Najjar, Isabelle Boulay‐Coletta, Balkis El Khouni, Mohamad Abou Chakra, Xavier Durand, Albert Semaan, Igor Duquesne   +8 more
wiley   +1 more source

Factors Affecting Surgical Outcomes Following Rotationplasty in Paediatric Sarcoma: A Literature Review

ANZ Journal of Surgery, EarlyView.
Rotationplasty is a durable limb‐salvage option for paediatric lower‐limb sarcoma. Across 58 studies and 1,217 patients, long‐term functional, psychosocial, and quality‐of‐life outcomes were favourable, often surpassing amputation and endoprosthetic reconstruction.
Rachel H. Ko, Stewart Morrison, Daniel J. Wilks   +2 more
wiley   +1 more source

Sudden Unexpected Death in Infancy in New Zealand: A Review of Coronial Recommendations

Acta Paediatrica, EarlyView.
ABSTRACT Aims Sudden Unexpected Death in Infancy (SUDI) remains a leading cause of post‐neonatal mortality in Aotearoa New Zealand. We analysed New Zealand coronial findings and recommendations to identify recurring modifiable risks, social determinants of health, and system‐level failures that might inform prevention strategies.
Edwin A. Mitchell, Stephanie F. Cowan, Barry J. Taylor   +2 more
wiley   +1 more source

‘Out of My Hands’: Palestinian Referral Care in East Jerusalem After October 7, 2023

Bioethics, EarlyView.
ABSTRACT This paper examines the moral experiences of Palestinian healthcare professionals working at a specialised referral hospital in East Jerusalem during the early months of the Gaza War. Drawing on semi‐structured interviews with hospital staff providing oncology care, it analyses how understandings of what constitutes “good” care in a context of
Pieter Dronkers, Zeina Amro
wiley   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, EarlyView.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer

Cancer Science, EarlyView.
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi, Sakura Hiraide Taniguchi, Yuya Yoshida   +2 more
wiley   +1 more source

Bridging Policy and Practice: A Mixed‐Methods Study of Child Maltreatment Prevention in a Southern Italian City

Child &Family Social Work, EarlyView.
ABSTRACT Effective child protection systems increasingly rely on integrated, multi‐agency responses to prevent and address child maltreatment. However, in many European welfare contexts, collaboration across services remains constrained by organizational fragmentation.
Caterina Balenzano, Elena Carletti, Maddalena Floriana Grassi   +2 more
wiley   +1 more source