Results 101 to 110 of about 848,680 (351)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Outcome of meningococcal septic shock in childhood [PDF]

, 2008
Yearly approximately 5000 children (0-18 years) are admitted to specialized pediatric intensive care units (PICU) in the Netherlands. Among these children, although relatively low in number, patients with meningococcal sepsis or septic shock form a well ...
Buysse, C.M.P. (Corinne)
core   +1 more source

Critical congenital heart disease screening by pulse oximetry in a neonatal intensive care unit. [PDF]

, 2014
ObjectiveCritical congenital heart disease (CCHD) screening is effective in asymptomatic late preterm and term newborn infants with a low false-positive rate (0.035%).
Carrion, V, Lakshminrusimha, S, Manja, V, Mathew, B   +3 more
core   +2 more sources

Integration of Pediatric Palliative Care Into Cardiac Intensive Care: A Champion-Based Model

Pediatrics, 2019
We propose a novel conceptual model for PPC integration into the traditionally cure-oriented CICU using interdisciplinary PPCCs. Integration of pediatric palliative care (PPC) into management of children with serious illness and their families is ...
K. Moynihan, Jennifer M. Snaman, E. Kaye, W. Morrison, A. Dewitt, L. Sacks, Jess L. Thompson, Jennifer M. Hwang, V. Bailey, D. Lafond, J. Wolfe, E. Blume   +11 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Decreased NK cell count is a high-risk factor for convulsion in children with COVID-19

BMC Infectious Diseases, 2023
Background The neurological symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of increasing concern. Convulsions are among the main neurological manifestations reported in children with coronavirus disease-2019 (COVID-19)
Ting Shi, Yuanxi Bian, Jiahui Wu, Xiaohong Li, Jianping Deng, Tao Feng, Linlin Huang, Xiaoxing Kong, Jianmei Tian   +8 more
doaj   +1 more source

Time series analysis as input for clinical predictive modeling: Modeling cardiac arrest in a pediatric ICU [PDF]

, 2011
BACKGROUND: Thousands of children experience cardiac arrest events every year in pediatric intensive care units. Most of these children die. Cardiac arrest prediction tools are used as part of medical emergency team evaluations to identify patients in ...
Curtis E Kennedy, James P Turley
core   +3 more sources

Pediatric admissions that include intensive care: a population-based study

BMC Health Services Research, 2018
BackgroundPediatric admissions to intensive care outside children’s hospitals are generally excluded from registry-based studies. This study compares pediatric admission to specialist pediatric intensive care units (PICU) with pediatric admissions to ...
I. Ibiebele, C. Algert, J. Bowen, C. Roberts   +3 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Report on advances for pediatricians in 2018: allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology, nutrition, respiratory tract disorders and surgery. [PDF]

, 2019
This review reported notable advances in pediatrics that have been published in 2018. We have highlighted progresses in allergy, cardiology, critical care, endocrinology, hereditary metabolic diseases, gastroenterology, infectious diseases, neonatology ...
Bernasconi S, Borrelli M, Caffarelli C, Corsello G., Di Pinto R, Gaeta V, Iovane B, Mastrorilli C, Petraroli M, Santamaria F, Santoro A   +10 more
core   +2 more sources