Results 101 to 110 of about 171,275 (311)

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Association of SCN1A Gene Polymorphisms with Sodium Valproate Resistance in Pediatric Epilepsy: A Retrospective Case-Control Study

Neuropsychiatric Disease and Treatment
Huiyu Wang,* Tingting Geng,* Na Deng Department of Pediatric Intensive Care Unit, Shiyan Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, People’s Republic of China*These authors contributed equally to this ...
Wang H, Geng T, Deng N
doaj  

Research on age-stratified prevention and control strategies for pediatric RSV infection based on disease burden disparities

BMC Infectious Diseases
Introduction Due to the lack of effective antiviral treatments for respiratory syncytial virus, therefore, understanding the age-specific disparities in the burden of RSV infection can help identify targeted interventions.
Jingwen Ni, Junyu Dong, Zhihui Du, Mengxin Zhao, Lele Li, Xiaoqiao Zhang, Kenan Fang   +6 more
doaj   +1 more source

Evaluation of Enteral Nutrition Applications in Pediatric Intensive Care Units in Türkiye

Objective: Enteral nutrition practices in pediatric intensive care units (PICUs) in Türkiye and all around the world are mostly performed in accordance with an expert opinion due to the inadequacy of evidence-based practices.
Gülzade Uysal, Duygu Sönmez Düzkaya, Tülay Yakut   +2 more
core   +1 more source

Construction and psychometric testing of the EMPATHIC questionnaire measuring parent satisfaction in the pediatric intensive care unit [PDF]

, 2010
PURPOSE: To construct and test the reliability and validity of the EMpowerment of PArents in THe Intensive Care (EMPATHIC) questionnaire measuring parent satisfaction in the pediatric intensive care unit (PICU).
Hazelzet, J.A., Jan A. Hazelzet, van Goudoever, Johannes B., Latour, J.M., van Heerde, M., Dullaart, E. (Eugenie), Neef, M. de, Van Dam, N., de Neef, M, Verlaat, C.W.M. (Carin), Albers, Marcel J. I. J., Jos M. Latour, Goudoever, J.B. (Hans) van, Albers, MJIJ, Duivenvoorden, Hugo, Heerde, M. (Marc) van, Nicolette A. M. van Dam, Van Vught, E., Heerde, M. van, Verlaat, CWM, Vught, E.M. (Elise) van, Duivenvoorden, Hugo J., de Neef, M., Dam, N.A.M. van, Neef, M. (Marjorie) de, Dullaart, Eugenie, Latour, J.M. (Jos), Albers, M.J.I.J. (Marcel), van Goudoever, J.B., Verlaat, Carin W. M., Hazelzet, Jan A., van Vught, EM, Duivenvoorden, H., Dullaart, E., Duivenvoorden, H.J. (Hugo), Van Goudoever, J., Albers, M.J.I.J., de Neef, Marjorie, Marc van Heerde, van Vught, E.M., Verlaat, C., Latour, Jos M., Marjorie de Neef, Carin W. M. Verlaat, Johannes B. van Goudoever, Verlaat, C.W.M., van Dam, NAM, Hugo J. Duivenvoorden, Vught, E.M. van, Marcel J. I. J. Albers, Elise M. van Vught, Goudoever, J.B. van, Dullaart, E, Hazelzet, Jan, Eugenie Dullaart, Dam, N.A.M. (Nicolette) van, van Dam, N.A.M., van Vught, Elise M., Latour, Jos, Hazelzet, J.A. (Jan), van Heerde, Marc, Albers, M., van Heerde, M, Hazelzet, J., Duivenvoorden, H.J., van Dam, Nicolette A. M., Goudoever, Johan   +66 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Assessment of Phoenix Sepsis Score, pSOFA, PELOD-2, and PRISM III in Pediatric Intensive Care

Background/Objectives: Early identification of pediatric sepsis complications in intensive care is challenging and requires improved diagnostic tools. This study aimed to compare the Phoenix Sepsis Score (PSS), pSOFA, PELOD-2, and PRISM III in assessing ...
Violeta Iotova, Adriana Hadzhieva-Hristova, Ralitza Georgieva, Temenuga Stoeva, Darina Krumova   +4 more
core   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source