Results 151 to 160 of about 5,715,596 (356)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett   +7 more
wiley   +1 more source

Research on age-stratified prevention and control strategies for pediatric RSV infection based on disease burden disparities

open access: yesBMC Infectious Diseases
Introduction Due to the lack of effective antiviral treatments for respiratory syncytial virus, therefore, understanding the age-specific disparities in the burden of RSV infection can help identify targeted interventions.
Jingwen Ni   +6 more
doaj   +1 more source

Evaluation of Enteral Nutrition Applications in Pediatric Intensive Care Units in Türkiye

open access: yes
Objective: Enteral nutrition practices in pediatric intensive care units (PICUs) in Türkiye and all around the world are mostly performed in accordance with an expert opinion due to the inadequacy of evidence-based practices.
Gülzade Uysal   +2 more
core   +1 more source

End-of-life practices in seven Brazilian pediatric intensive care units

open access: yes, 2008
Objective: To evaluate the incidence of life support limitation and medical practices in the last 48 hrs of life of children in seven Brazilian pediatric intensive care units (PICUs). Design.
TROSTER, Eduardo   +8 more
core   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

open access: yesAdvanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song   +14 more
wiley   +1 more source

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

open access: yesAdvanced Materials, EarlyView.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang   +10 more
wiley   +1 more source

Turkish Society of Pediatric Emergency and Intensive Care Medicine Neurocritical Care Study Group Stroke in Critically Ill Children [PDF]

open access: yes
Stroke is a disease whose differential diagnosis is not easy because its symptoms and signs can be seen in many neurologic diseases. When neurological examination, clinical findings and radiological imaging are evaluated together, neurological ...
Pınar Yazıcı Özkaya   +15 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

open access: yesAdvanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng   +4 more
wiley   +1 more source

Assessment of Phoenix Sepsis Score, pSOFA, PELOD-2, and PRISM III in Pediatric Intensive Care

open access: yes
Background/Objectives: Early identification of pediatric sepsis complications in intensive care is challenging and requires improved diagnostic tools. This study aimed to compare the Phoenix Sepsis Score (PSS), pSOFA, PELOD-2, and PRISM III in assessing ...
Violeta Iotova   +4 more
core   +1 more source

Fast Hugs with Intensive Care Unit

open access: yes, 2014
Mnemonics are commonly used in medical procedures as cognitive aids to guide clinicians all over the world. The mnemonic ‘FAST HUG’ (Feeding, Analgesia, Sedation, Thromboembolic prophylaxis, Head-of-bed elevation, stress Ulcer prevention, and Glycemic ...
Rıza Hakan Erbay   +3 more
core   +1 more source

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