Results 171 to 180 of about 5,715,596 (356)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Peptide-based versus standard polymeric enteral nutrition in the PICU: a multicenter observational study

Frontiers in Nutrition
BackgroundNutritional guidelines recommend initiating enteral nutrition with standard polymeric formula (SPF) in critically ill children. Peptide-based formulas (PBF) have been increasingly used to improve enteral nutrition and reduce related ...
Merve Misirlioglu Celik, Dincer Yildizdas, Faruk Ekinci, Sevinc Puren Yucel Karakaya, Muhterem Duyu, Ayse Asik, Abdullah Akkus, Fatih Akin, Hatice Feray Ari, Eylem Kiral, Ener Cagri Dinleyici, Hatice Elif Kinik Kaya, Nazik Yener, Mehmet Alakaya, Ali Ertug Arslankoylu, Busra Segmen, Ozden Ozgur Horoz, Hasan Ali Telefon, Tanil Kendirli, Eda Eyduran, Neslihan Zengin, Nihal Akcay, Ilyas Bingol, Sinan Yavuz, Ali Avci, Nazan Ulgen Tekerek, Murat Erdal, Feyza Incekoy Girgin, Makbule Nilufer Yalindag, Muhammed Udurgucu, Caglar Odek, Didar Arslan, Gurkan Atay, Hazal Ceren Tugrul, Hatice Albayrak   +34 more
doaj   +1 more source

Use of Echocardiography in The Intensive Care Unit

, 2012
Echocardiography is a diagnosis and research method that allows us to learn about anatomical and mechanical functions of the heart by using ultrasonic sound waves.
Burak Eşkin, Ahmet Coşar
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Prediction of Gastric Residual Volume by Ultrasonography in Critically Ill Children Undergoing Enteral Nutrition

Critical Care Research and Practice
Conclusion: The results suggest that ultrasound-based monitoring can predict GRV in critically ill children. In addition, the qualitative grading system can differentiate between high and low GRV, potentially serving as a rapid screening tool for ...
Jinjiu Hu, Qiaoying Zhang, Xin Wan, Hui Zhang, Qiao Shen, Fei Li, Ye Cai, Yuqian Meng, Peng Liu, Xianlan Zheng   +9 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up – towards an international prognostication guideline

Resuscitation Plus
Aims: Pediatric cardiac arrest is associated with high mortality and significant morbidity among survivors. International guidelines for prognostication remain limited due to small heterogeneous patient populations, variable post-return of circulation ...
Marijn Albrecht, Maayke Hunfeld, Annemieke Arkesteijn-Muit, Karolijn Dulfer, Matthijs de Hoog, Gabry de Jong, Rogier de Jonge, Aldert Lamoré, Vinay Nadkarni, Corinne Buysse, Nikki Schoenmaker, Annelies van Zwol, Geanne Krabben-de Vlaam, Nicole de la Haye, Jennifer Walker   +14 more
doaj   +1 more source

Structure and Function: Planning a New Intensive Care Unit to Optimize Patient Care

, 2014
To survey the recent medical literature reporting effects of intensive care unit (ICU) design on patients’ and family members’ well-being, safety and functionality. Features of ICU design linked to the needs of patients and their family are single-rooms,
Jozef Kesecioğlu
core   +1 more source