Results 31 to 40 of about 682,435 (246)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Is ChatGPT a Useful Tool for Ophthalmology Practice?

Acta Medica Alanya
Aim: This study aimed to assess ChatGPT-3.5's performance in ophthalmology, comparing its responses to clinical case-based and multiple-choice (MCQ) questions. Methods: ChatGPT-3.5, an AI model developed by OpenAI, was employed.
Dilara Özkoyuncu, Fuat Yavrum
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Telemedicine Follow-Up for Intravitreal Bevacizumab Injection in the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) Cohort

Clinical Ophthalmology, 2020
Marco H Ji,1 Natalia F Callaway,1 Margaret A Greven,2 Daniel Vail,1 Darius M Moshfeghi1 1Byers Eye Institute, Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California; 2Department of
Ji MH, Callaway NF, Greven MA, Vail D, Moshfeghi DM   +4 more
doaj  

Patient-reported outcome measures for retinoblastoma: a scoping review

Journal of Patient-Reported Outcomes, 2020
Background Retinoblastoma is a childhood retinal cancer with lifelong consequences such as vision loss and increased risk of second cancer. Patient-reported outcome measures (PROMs) are instruments that measure outcomes related to health directly ...
Ana Janic, Sylvie Bowden, Sarah Levy, Jennifer Stinson, Helen Dimaras   +4 more
doaj   +1 more source

Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months

, 2020
Importance: Optic neuritis (ON) in children is uncommon. There are limited prospective data for visual acuity (VA) outcomes, associated diseases, and neuroimaging findings.
Repka, Michael X., Shah, Veeral S., Holmes, Jonathan M., Wallace, David K., Waldman, Amy T., Borchert, Mark S., Khanna, Sangeeta, Kraker, Raymond T., Graves, Jennifer S., Liu, Grant T., Cotter, Susan A., Pineles, Stacy L., Heidary, Gena, Kupersmith, Mark J., Grant T. Liu, Michael X. Repka, Susan A. Cotter, Jennifer S. Graves, Amy T. Waldman, Mark S. Borchert, Stacy L. Pineles, Sangeeta Khanna, Mark J. Kupersmith, Veeral S. Shah, Jonathan M. Holmes, Gena Heidary, null null, Raymond T. Kraker, David K. Wallace   +28 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Corneal Biomechanical Characteristics and Correlation Analysis in Children With Different Refractive States

Journal of Ophthalmology
Conclusions: Corneal stiffness seems to decrease with the increase of SE. The changes of SSI, PD, and A2V were statistically significant and can be predictors of myopia progression in adolescents aged 5–13 years.
Xiao Jing Bai, Yan Hua Wang, Tian Gang Liang, Qi Zhao, Meng Fan Cui, Jie Cheng, Wei Xiang Nie   +6 more
doaj   +1 more source

Neuro-Ophthalmological Manifestations of Craniosynostosis: Current Perspectives

Eye and Brain, 2021
Michael Duan,1 Jesse Skoch,2 Brian S Pan,3 Veeral Shah4,5 1Baylor College of Medicine, School of Medicine, Houton, TX, USA; 2Cincinnati Children’s Hospital Medical Center, Division of Pediatric Neurosurgery, Cinicinnati, OH, USA; 3Cincinnati ...
Duan M, Skoch J, Pan BS, Shah V
doaj  

Ocular and Systemic Findings in COL2A1 and COL11A1 Stickler Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Stickler syndrome is most commonly caused by variants in COL2A1 and COL11A1 genes. The purpose of this study was to describe genetic variants and phenotypes in COL2A1 and COL11A1 Stickler syndrome. We performed a retrospective genotype–phenotype evaluation of COL2A1 and COL11A1 Stickler syndrome subjects. Thirty‐two subjects with COL2A1 and 13
Aileen G. MacLachlan, Jessica A. Kraker, Denise J. Morgan, Lisa A. Schimmenti, M. Elizabeth Hartnett, Eileen S. Hwang   +5 more
wiley   +1 more source