Results 181 to 190 of about 863,421 (266)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Meeting learners where they are: case presentations in remote pediatric critical care education. [PDF]

Front Pediatr
Aromolaran A, Nagar R, Adja-Sai C, Alce R, Bacha T, Fentie S, Kilba MC, Lilite S, Marcus BS, Mehu M, Mohammed A, Nnajekwu U, Nwankwor O, Nzeduba C, Owusu L, Appiah JA, Owusu-Sekeyre F, Oguonu T, Prabarkaran P, Wu A, Silverman AM, Tamene A, Udemba C, Haile BW, Zakariah S, Canarie MF.   +25 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

AK8 deficiency causes primary ciliary dyskinesia by disrupting energy homeostasis in the airways. [PDF]

Am J Respir Crit Care Med
Thüß D, Liu Y, Dougherty GW, Maas EJ, He J, Zhou X, Schultz A, Nielsen KG, Omran H, Luo H, AK8 Study Group.   +10 more
europepmc   +1 more source

Defining and Promoting Pediatric Pulmonary Health: A NHLBI Workshop Executive Summary

, 2023
Aruna Natarajan, Banerjee, Koyeli, Lachowicz-Scroggins, Marrah, Koyeli Banerjee, Davis, Stephanie D., Marrah Lachowicz-Scroggins, Laposky, Aaron, Stephanie D. Davis, Josh Fessel, Fessel, Josh, James F. Chmiel, Aaron Laposky, Chmiel, James F., Natarajan, Aruna   +13 more
core   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Outcomes of down syndrome-related myeloid leukemia in Turkiye: a multicenter retrospective observational cohort study by the Turkish Pediatric Hematology Association. [PDF]

Ann Hematol
Düzenli Kar Y, Ören H, Sezgin Evim M, Zengin E, Gün E, Karadaş N, Yılmaz Karapınar D, Albayrak C, Ünal S, Karahan F, Söker M, Uzel VH, Akyay A, Öncül Y, Bahadır A, Orhan MF, Çakı Kılıç S, Tufan Taş B, Güler Kazancı E, Orhaner B, Karapınar TH, Aral YZ, Yaralı N, Fettah A, Özkaya G, Meral Güneş A.   +25 more
europepmc   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

To the Editor: Sharing the Full Game Enhances Replicability and Impact of Studies of Card and Board Games in Health Professions Education. [PDF]

J Grad Med Educ
Cosimini M, Chiang A.
europepmc   +1 more source