Results 61 to 70 of about 739,276 (380)

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics

open access: yesItalian Journal of Pediatrics, 2018
The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to the disease. The following areas were reviewed:
G. Valerio   +57 more
semanticscholar   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso   +12 more
wiley   +1 more source

Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet

open access: yesPharmacy Practice, 2021
Background: Medication error is a global threat to patient safety, particularly in pediatrics. Yet, this issue remains understudied in this population, in both hospital and community settings.
Christine Azar   +8 more
doaj   +1 more source

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang   +6 more
wiley   +1 more source

Psoriasis in Pediatrics

open access: yesВопросы современной педиатрии, 2020
Psoriasis is one of the most debatable topics in modern dermatology among the wide range of other dermatological diseases in childhood. The article provides current data on the epidemiology of psoriasis, its clinical features in different age groups, its
Andrey L. Bakulev   +1 more
doaj   +1 more source

Rejoinder: "Spatial accessibility of pediatric primary healthcare: Measurement and inference" [PDF]

open access: yesAnnals of Applied Statistics 2014, Vol. 8, No. 4, 1961-1965, 2015
Rejoinder of "Spatial accessibility of pediatric primary healthcare: Measurement and inference" by Mallory Nobles, Nicoleta Serban and Julie Swann [arXiv:1501.03626].
arxiv   +1 more source

Factors That Influence the Choice of Academic Pediatrics by Underrepresented Minorities

open access: yesPediatrics, 2019
In this study, we address what experiences influence URMs in pursuing academic pediatric medicine. OBJECTIVES: Our objective for this study was to explore the experiences of faculty in academic pediatrics who are underrepresented minorities (URMs) at 2 ...
Gabrina Dixon   +5 more
semanticscholar   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1002-1028, April 2025.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch   +11 more
wiley   +1 more source

Rating Scales in Attention Deficit Disorder

open access: yesPediatric Neurology Briefs, 1989
A comparison of parent, teacher, and child performance rating scales in the diagnosis and follow-up of methylphenidate treated children with ADDH is reported from Developmental Pediatrics, San Antonio, TX; Department of Pediatrics, Madigan Army Medical ...
J Gordon Millichap
doaj   +1 more source

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