Results 61 to 70 of about 739,276 (380)
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale+9 more
wiley +1 more source
The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to the disease. The following areas were reviewed:
G. Valerio+57 more
semanticscholar +1 more source
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso+12 more
wiley +1 more source
Background: Medication error is a global threat to patient safety, particularly in pediatrics. Yet, this issue remains understudied in this population, in both hospital and community settings.
Christine Azar +8 more
doaj +1 more source
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang+6 more
wiley +1 more source
Psoriasis is one of the most debatable topics in modern dermatology among the wide range of other dermatological diseases in childhood. The article provides current data on the epidemiology of psoriasis, its clinical features in different age groups, its
Andrey L. Bakulev+1 more
doaj +1 more source
Rejoinder: "Spatial accessibility of pediatric primary healthcare: Measurement and inference" [PDF]
Rejoinder of "Spatial accessibility of pediatric primary healthcare: Measurement and inference" by Mallory Nobles, Nicoleta Serban and Julie Swann [arXiv:1501.03626].
arxiv +1 more source
Factors That Influence the Choice of Academic Pediatrics by Underrepresented Minorities
In this study, we address what experiences influence URMs in pursuing academic pediatric medicine. OBJECTIVES: Our objective for this study was to explore the experiences of faculty in academic pediatrics who are underrepresented minorities (URMs) at 2 ...
Gabrina Dixon+5 more
semanticscholar +1 more source
Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch+11 more
wiley +1 more source
Rating Scales in Attention Deficit Disorder
A comparison of parent, teacher, and child performance rating scales in the diagnosis and follow-up of methylphenidate treated children with ADDH is reported from Developmental Pediatrics, San Antonio, TX; Department of Pediatrics, Madigan Army Medical ...
J Gordon Millichap
doaj +1 more source