Results 71 to 80 of about 863,421 (266)

Outcome of Adolescents with Acute Lymphoblastic Leukemia Treated by Pediatrics versus Adults Protocols

Advances in Hematology, 2014
Objective. Several studies showed better outcome in adolescents and young adults with acute lymphoblastic leukemia (ALL) treated with pediatrics protocols than similarly aged patients treated with adults protocols, while other studies showed similar ...
Abeer Ibrahim, Amany Ali, Mahmoud M. Mohammed   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Teaching prevention in pediatrics

, 2012
Pediatrics has attempted to inculcate the "culture of prevention" into practice, both through anticipatory guidance in well-child care and through behavioral interventions in sick care.
Greenberg, Larrie, Cheng, Tina L., Keller, David M., Loeser, Helen   +3 more
core  

Fostering Tomorrow: Uniting Artificial Intelligence and Social Pediatrics for Comprehensive Child Well-being

This comprehensive review explores the integration of artificial intelligence (AI) in the field of social pediatrics, emphasizing its potential to revolutionize child healthcare.
Murat Gülşen, Sıddıka Songül Yalçın, Yalcin, Siddika Songul, Gulden, Murat   +3 more
core   +1 more source

Diuretics in pediatrics

, 2023
Diuretics are frequently prescribed drugs and help managing several pathological conditions, including acute and chronic kidney disease, nephrotic syndrome, congestive heart failure, ascites, systemic and pulmonary hypertension.
Chiara Zollinger, Lava, SAG, Damien Schaffner, Sekarski, N., Di Bernardo, S., Stefano Di Bernardo, Nicole Sekarski, Schaffner, D., Sebastiano A. G. Lava, Chehade, H., Hassib Chehade, Zollinger, C.   +11 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Gut Microbiota Dysbiosis and Gut–Nasal Axis Alterations in Preschool Children with Allergic Rhinitis and Functional Constipation

Journal of Asthma and Allergy
Weikeng Yang,1,2,* Xiaoli Li,3,* Chunyan Wang,4 Xiuyun Li,3 Congfu Huang3 1Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 2Department of Pediatrics, The Second Affiliated Hospital, School of Medicine ...
Yang W, Li X, Wang C, Li X, Huang C
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Impact of Adenotonsillectomy on Quality of Life in Pediatric Obstructive Sleep Apnoea (OSA): Insights from the OSA-18 Questionnaire

Nature and Science of Sleep
Montaha Al-Iede,1,2 Zaina Alhelou,2 Nour Hamdan,2 Basil Alramahi,2 Shada Algharibeh,2 Ahmad Qarajeh,2 Sara Ishtaieh,2 Ahmad Al Nsour,3 Mai AlAdwan,2 Abdulrahman Alhanbali,2 Rima A Sinan,2 Lubna Khreesha3 1Division of Pediatric Pulmonology and Sleep ...
Al-Iede M, Alhelou Z, Hamdan N, Alramahi B, Algharibeh S, Qarajeh A, Ishtaieh S, Al Nsour A, AlAdwan M, Alhanbali A, Sinan RA, Khreesha L   +11 more
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