Results 71 to 80 of about 1,297,971 (299)
, 2019 Computer gaming greatly profited from the worldwide availability of the Internet in the mid-1990s and the consequent popularization of multiplayer online games (MOGs). A very popular genre of MOGs are massively multiplayer online games (MMOGs), which are large-scale applications supporting a large amount of players worldwide concurrently sharing a real-
Ricci L., Carlini E.
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Symmetric Replication for Structured Peer-to-Peer Systems [PDF]
, 2005 Structured peer-to-peer systems rely on replication as a basic means to provide fault-tolerance in presence of high churn. Most select replicas using either multiple hash functions, successor-lists, or leaf-sets.
Ghodsi, Ali +2 more
core +2 more sources
Peer-Assisted Information-Centric Network (PICN): A Backward Compatible Solution
IEEE Access, 2017 Information-centric networking (ICN) is a promising solution for most of Internet applications where the content represents the core of the application.
Zeinab Zali +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Storage and Search in Dynamic Peer-to-Peer Networks
, 2013 We study robust and efficient distributed algorithms for searching, storing, and maintaining data in dynamic Peer-to-Peer (P2P) networks. P2P networks are highly dynamic networks that experience heavy node churn (i.e., nodes join and leave the network ...
Augustine John +6 more
core +1 more source
Peer-to-Peer Semantic Wikis [PDF]
, 2009 This paper presents SWOOKI the first peer-to-peer semantic wiki. A P2P semantic wiki combines advantages of both semantic wikis and P2P Wikis. A P2P semantic wiki network is composed of a set of interconnected autonomous servers that can dynamically join and leave the network.
Skaf, Hala +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source