Results 131 to 140 of about 97,038 (278)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

“It felt like a weight was being taken off of my shoulders”: findings from an intervention to support migrant adolescents and young people in KwaZulu-Natal, South Africa

SSM - Mental Health
In South Africa, many young people relocate from rural to urban areas for education, attending day schools while residing in rented accommodation. Migration exposes them to risk, including alcohol and drug abuse, sexual exploitation and violence.
Nondumiso Dlamini, Siphesihle Hlongwane, Carina Herbst, Maryam Shahmanesh, Nothando Ngwenya, Sarah Bernays, Janet Seeley   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Peer-to-peer accommodation networks: pushing the boundaries [PDF]

, 2017
Peer-to-Peer Accommodation Networks: Pushing the boundaries is the first book to provide an in-depth analysis of the business model of Airbnb, to discuss factors facilitating the transition of peer-to-peer networks from niche market to mainstream accommodation providers, and to predict that the next step of development for peer-to-peer accommodation ...
openaire   +3 more sources

Culture as a catalyst for regenerative co-creation: the role of yuanfen in driving customer voice through social bonds in P2P accommodation

Frontiers in Psychology
IntroductionAs tourism shifts from sustainability toward regeneration, active customer participation has become essential for revitalizing the peer-to-peer (P2P) accommodation sector.
Huifang Liu, Huifang Liu, Xiaoting Huang
doaj   +1 more source

Peer-to-peer as a travel accommodation option and the customer value [PDF]

, 2016
The purpose of the study was to investigate the concept of peer-to-peer accommodation as a travel lodging option from the customers’ point of view and the reasons for choosing that.
Rakovets, Elizaveta
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

From host's descriptions to guests' reviews: Semantic similarities

Annals of Tourism Research Empirical Insights
This study investigates the semantic alignment between Airbnb property descriptions and guest reviews. Word2Vec embeddings and affinity propagation clustering are used to identify granular semantic concepts, enabling a detailed comparison of the two text
Mariana Cavique, Ricardo Ribeiro, Fernando Batista, Antónia Correia   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exploring consumers’ continuance intention to use peer-to-peer accommodation service: The role of psychological ownership

, 2019
EXPLORING CONSUMERS’ CONTINUANCE INTENTION TO USE PEER-TO-PEER ACCOMMODATION SERVICE: THE ROLE OF PSYCHOLOGICAL OWNERSHIP Exploring consumers’ continuance intention to use peer-to-peer accommodation service: The role of psychological ownership (-
Sun, Yongqiang, Wang, Nan, Liu, Dina, Guo, Yanping   +3 more
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