Results 141 to 150 of about 181,200 (325)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Peer-to-peer accommodation networks: pushing the boundaries [PDF]

, 2017
Peer-to-Peer Accommodation Networks: Pushing the boundaries is the first book to provide an in-depth analysis of the business model of Airbnb, to discuss factors facilitating the transition of peer-to-peer networks from niche market to mainstream accommodation providers, and to predict that the next step of development for peer-to-peer accommodation ...
openaire   +3 more sources

“It felt like a weight was being taken off of my shoulders”: findings from an intervention to support migrant adolescents and young people in KwaZulu-Natal, South Africa

SSM - Mental Health
In South Africa, many young people relocate from rural to urban areas for education, attending day schools while residing in rented accommodation. Migration exposes them to risk, including alcohol and drug abuse, sexual exploitation and violence.
Nondumiso Dlamini, Siphesihle Hlongwane, Carina Herbst, Maryam Shahmanesh, Nothando Ngwenya, Sarah Bernays, Janet Seeley   +6 more
doaj   +1 more source

Impacts of Covid-19 on peer-to-peer accommodation platforms: Host perceptions and responses. [PDF]

Int J Hosp Manag, 2020
Farmaki A, Miguel C, Drotarova MH, Aleksić A, Časni AČ, Efthymiadou F.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

It's Not Just About Money in Peer-To-Peer Accommodation

, 2022
Anil Gupta, Honeyka Mahajan, Ravinder Dogra   +2 more
openalex   +2 more sources

Peer-to-peer accommodation prices: City listing concentration and host listing share [PDF]

, 2022
Elena Bárcena‐Martín, Beatriz Benítez-Aurioles, Salvador Pérez‐Moreno   +2 more
openalex   +1 more source

Websites as Facilities Under ADA Title III [PDF]

, 2017
Title III of the Americans with Disabilities Act requires public accommodations—private entities that offer goods or services to the public—to be accessible to individuals with disabilities.
Brunner, Ryan C.
core   +1 more source