Results 61 to 70 of about 86,868,515 (236)
Stakeholders’ perceptions towards the barriers and challenges to Airbnb
Mенаџмент у хотелијерству и туризмуPurpose – The current exploratory research aims to investigate the barriers and challenges to the use of Airbnb as a sharing economy platform in the most visited destinations, namely Antalya and Istanbul in Türkiye.
Nurullah Cihan Ağbay +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Rede peer-to-peer para imagem médica [PDF]
, 2010 Mestrado em Engenharia de Computadores e TelemáticaNos últimos anos, a imagem médica em formato digital tem sido uma ferramenta cada vez mais importante quer para o diagnóstico médico quer para o auxílio ao tratamento.
Ferreira, Carlos André Marques Viana
core
Attrition Defenses for a Peer-to-Peer Digital Preservation System
, 2004 In peer-to-peer systems, attrition attacks include both traditional, network-level denial of service attacks as well as application-level attacks in which malign peers conspire to waste loyal peers' resources.
David S. H. Rosenthal +10 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
, 2020 The specific objectives that guided the study were to identify the customer profile of P2P accommodation and Budget Hotel customers, establish the extent to which customer needs for P2P accommodation and Budget Hotels influence choice of ...
Muthengi, Dr. Sisinio +2 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source