Results 71 to 80 of about 181,200 (325)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Living a frozen life: a qualitative study on asylum seekers’ experiences and care practices at accommodation centers in Sweden

open access: yesConflict and Health, 2022
Background Forced migrants fleeing conflict and violence face a high risk of mental health problems due to experiences before displacement, perilous journeys, and conditions in the new host societies.
Charlotta van Eggermont Arwidson   +4 more
doaj   +1 more source

A Study of Onefinestay’s guest experience in comparison to high-end hotels: Evidence from Onefinestay’s blog analysis [PDF]

open access: yes, 2018
Purpose-This paper aims at providing insight of guest experience and satisfaction at HPA in comparison to ordinary peer-to-peer accommodation (OPA) and luxury hotel. Although many recent researches have been done in the OPA context, the majority is about
Fan, Xuefeng, Hoang, My Linh
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A Drama Theory Analysis of Host-Guest Interaction In Peer-To-Peer Accommodation

open access: yesAPMBA (Asia Pacific Management and Business Application), 2020
Peer-to-peer economy is characterised by asymmetric information, economy risks, and social uncertainty that may be arisen in unpredictable time. In hospitality industries, peer-to-peer accommodation allows people to rent unoccupied room or properties to ...
Lisa Putri Kusuma, Pri Hermawan
doaj  

Exploring Airbnb Host Wellbeing and Host-Guest Conflicts in Network Hospitality

open access: yesFrontiers in Psychology, 2022
Despite a plethora of studies examining hosting experiences of Airbnb guests, the wellbeing of hosts has received limited attention. Drawing on both top-down and bottom-up theories of wellbeing, we explore the different ways in which Airbnb enhances or ...
Lucie K. Ozanne, Girish Prayag
doaj   +1 more source

An Examination of Relational-interdependent Self-construal, Communal Strength, and Pro-relationship Behaviors in Friendships [PDF]

open access: yes, 2011
Individual differences in relational-interdependent self-construal (RISC) are associated with positive relationship characteristics. This suggests that RISC is positively associated with the degree to which individuals view their relationships as ...
Clark, Eddie M   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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