Results 61 to 70 of about 1,664,289 (275)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Revista Crítica de Ciências Sociais, 2019 A secure peer attachment appears in the literature as a protective factor against bullying behavior. The present study seeks to test the predictor effect of peer attachment on different types of bullying and to examine the mediating role of gender on the
Denise Dias +2 more
doaj
Malaysian Journal of Learning and Instruction, 2017 Purpose – Building upon attachment theory and emerging theory, the current study was aimed at examining the effect of peer attachment in predicting adjustment to life in university among freshmen in a public unirvsity in East Malaysia.
Walton Wider +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Jurnal Ilmu Keluarga dan Konsumen, 2017 Adolescents delinquency that leads to criminal conduct had to be reviewed to identify the factor that causes it. This study aimed to analyze the influence of mother-adolescent, father-adolescent, and peer group-adolescent attachments on adolescent ...
Wihelmina Fitriani, Dwi Hastuti
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Jurnal Bimbingan dan Konseling TerapanThis study explores the relationship between peer attachment and emotional regulation in high school students at the Special State School in Salatiga, Indonesia, focusing on those with special needs. Utilizing a quantitative approach with a correlational
Made Loka Santi Ari +1 more
doaj +1 more source
Parents or Peers? Predictors of Prosocial Behavior and Aggression: A Longitudinal Study
Frontiers in Psychology, 2019 The aim of this longitudinal study was to determine the associations among peer attachment, warmth from the mother and father, strict control by the mother and father, prosocial behavior, and physical and verbal aggression in adolescence.
Elisabeth Malonda +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source