Results 111 to 120 of about 15,931,373 (396)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

The Economics of Education: Vouchers and Peer Group Effects [PDF]

open access: yes
Lessons from the history of US school reforms and empirical analysis have painted a picture of schools as complex institutions producing a product that is influenced by the various choices made by parents and school bureaucracies who respond to ...
Thomas J Nechyba
core  

Multicast in DKS(N, k, f) Overlay Networks [PDF]

open access: yes, 2003
Recent developments in the area of peer-to-peer computing show that structured overlay networks implementing distributed hash tables scale well and can serve as infrastructures for Internet scale applications.
Ali Ghodsi   +4 more
core   +7 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The Effect of Peer Support of Mothers of Children with Acute Lymphoblastic Leukemia on Quality of Life of Patients

open access: yesمراقبت پرستاری و مامایی ابن سینا, 2020
Background & Aim: Caring for a child with cancer can be deeply frustrating for parents with high levels of anxiety and psychological distress. Parents who suffer from high psychological stress have poorer performance in the family and health-related ...
Fereshteh Ghaljaei   +4 more
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

The Effect of Peer Group Education on Anxiety of Patients with Multiple Sclerosis [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2012
Introduction: Multiple Sclerosis (MS) is one of the most common chronic diseases of the central nervous system which causes mental disorders including anxiety in patients.
Ali Dehghani   +3 more
doaj  

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