Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Clinical supervisor's experiences of peer group clinical supervision during COVID-19: a mixed methods study. [PDF]
BMC NursDoody O +4 more
europepmc +1 more source
"Your Friends Do Matter": Peer Group Talk in Adolescence and Gender Violence Victimization. [PDF]
Children (Basel), 2021 Racionero-Plaza S +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Peer group-based online intervention program to empower families raising children with disabilities: protocol for a feasibility study using non-randomized waitlist-controlled trial. [PDF]
Pilot Feasibility Stud, 2022 Matsuzawa A +6 more
europepmc +1 more source
Sickness Absence and Peer Effects -Evidence from a Swedish Municipality [PDF]
In this paper we use detailed employment records to study to what extent sickness absence among work group colleagues influences individual sickness absence. Our results indicate an overall positive peer effect.
Ekblad, Kristin, Bokenblom, Mattias
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Facilitated Peer Group Mentoring for Underrepresented Biomedical Researchers: Facilitators' Experiences and Implications for Dissemination of a Curriculum. [PDF]
Chron Mentor CoachAvila B +5 more
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Effectiveness of peer-group therapy using community based participatory research model on medication adherence among patients of diabetes and/or hypertension: study protocol for a multi-centre cluster randomised trial in rural settings across India (PARTICIPATE study). [PDF]
TrialsReddy P +15 more
europepmc +1 more source