Results 61 to 70 of about 1,447,355 (302)
Behavioral Sciences, 2020 In the last few years, more children and adolescents healed from leukemia go back to their daily life, even if they can show some psycho-social difficulties.
Marta Tremolada +5 more
doaj +1 more source
BMC Public Health, 2021 Background Connectedness to family and peers is a key determinant of adolescent mental health. Existing research examining associations between social media use and social connectedness has been largely quantitative and has focused primarily on ...
Lizzy Winstone +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Implicit Theories of Peer Relationships [PDF]
Social Development, 2010 This research investigated the role of children's implicit theories of peer relationships in their psychological, emotional, and behavioral adjustment. Participants included 206 children (110 girls; 96 boys; M age = 10.13 years, SD = 1.16) who reported on their implicit theories of peer relationships, social goal orientation, need for approval ...
openaire +2 more sources
Childhood loneliness as a predictor of adolescent depressive symptoms: an 8-year longitudinal study [PDF]
, 2009 Childhood loneliness is characterised by children’s perceived dissatisfaction with aspects of their social relationships. This 8-year prospective study investigates whether loneliness in childhood predicts depressive symptoms in adolescence, controlling ...
A Gerson +65 more
core +5 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The relationship and effects of golf on physical and mental health:A scoping review protocol [PDF]
, 2016 Introduction Golf is a sport played in 206 countries worldwide by over 50 million people. It is possible that participation in golf, which is a form of physical activity, may be associated with effects on longevity, the cardiovascular, metabolic and ...
Archibald, D. +5 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Learning In the Visual Arts and the Worldviews of Young Children [PDF]
, 2007 This paper reports a research study into the effects of rich,sustained visual arts instruction on 103inner city 9-year-olds in two major US cities. We use the lenses of social learning theory, theories of motivation and self-efficacy, and recentresearch ...
James S. Catterall, Kylie A. Peppler
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source