Results 111 to 120 of about 2,877,555 (301)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Publishing scientific research: is there ground for new ventures? [PDF]
, 2008 This paper highlights some of the issues that have been reported in surveys carried out by the RIOJA (Repository Interface for Overlaid Journal Archives) project (http://www.ucl.ac.uk/ls/rioja).
Moyle, M., Polydoratou, P.
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
What Every Economist Should Know about the Evaluation of Teaching: A Review of the Literature [PDF]
Decades of research consistently show that student evaluations offer limited information on the effectiveness of teaching in economics. Such methods are at best valid for a relatively small set of factors that correlate with "good instruction." Even ...
Stephen B. DeLoach
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Recognition and reward system for peer-reviewers [PDF]
, 2018 Peer reviewing plays an important role in the academic publishing process that scrutinizes and provides feedback on the scientific work prior to publication.
Jan, Zeeshan
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Blogging on peer-reviewed research
, 2007 One of my main goals in this blog is to help non-scientists (Christian readers in particular) understand science and God's world, by reviewing and explaining recently-published scientific research.
openaire +1 more source
Peer reviewers’ conflicts of interest in biomedical research: scoping review
BMJ Evidence-Based MedicineBackgroundPeer review may improve the quality of research manuscripts and aid in editorial decisions, but reviewers can have conflicts of interest that impact on their recommendations.ObjectivesThe objective was to systematically map and describe the extent and nature of empirical research on peer reviewers’ conflicts of interest in biomedical research.
Christoffer Bruun Korfitsen +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source