Results 141 to 150 of about 2,859,402 (254)

Experiences and outcomes of peer navigation and support interventions for adolescents on HIV treatment in sub-Saharan Africa: protocol for a qualitative evidence synthesis. [PDF]

BMJ Open
van Wyk B, Mabuza BN, Petinger C.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Testing a mobile peer support intervention for persons with serious mental illness (DigiPer) in community mental health services: a feasibility study protocol. [PDF]

BMJ Open
Wang B, Mundal I, Fortuna K, Grønvik CKU, Eines TF, Muzny M, Skjærpe JN, Storm M.   +7 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comentários sobre artigo de Araújo: os critérios para revisão e publicação de artigos são evidentes?

Arquivos Brasileiros de Cardiologia
Paulo Roberto Benchimol-Barbosa
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Neural sensitivity to peer hierarchies: Risks for depressive symptoms for low status adolescents. [PDF]

J Res Adolesc
Capella J, Jorgensen NA, Kwon SJ, Maza MT, Prinstein MJ, Lindquist KA, Telzer EH.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Publication Literacy: Editors’ Advice on the Successful Submission and Acceptance of a Journal Article

Araştırma Temelli Etkinlik Dergisi
This article explores the growing practice of publication literacy and presents guidelines on how publication literacy can develop both writing skills and managing article submissions to a journal.
Laetus Lategan, Cecilé Swart, Desere Kokt   +2 more
doaj  

The role of online peer support in pregnancy: A scoping review. [PDF]

PLoS One
Morris H, Duaso M, Ijeomah-Orji M, Akester L, Roddy J, Samples J, Heighway K, Simpson N, Stacey T.   +8 more
europepmc   +1 more source