Results 171 to 180 of about 2,725,232 (305)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Non-Suicidal Self-Injury in Adolescents: A Systematic Review on Prevention and Intervention Programmes. [PDF]

J Child Adolesc Psychiatr Nurs
Escofet-Colet I, Casadó-Marín LC, Orós-Navas L, Raventós-Torner R.   +3 more
europepmc   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Navigating Challenges in Peer Support Work: Perspectives of Peer Supporters From a Stepped Care Intervention for Older Adults With Depressive Symptoms. [PDF]

Health Expect
Yiu EKL, Wong SMY, Lee JKQ, Ng ZLY, Leung DKY, Chan WC, Wong GHY, Lum TYS.   +7 more
europepmc   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

A Letter to the Editor: The Peer Review Process: Past, Present, and Future

British Journal of Biomedical Science
Ahmed A. Khalifa
doaj   +1 more source

Pharmacist Peer-Led Teaching Enhances Medical Undergraduate Prescribing: A Mixed-Methods Study. [PDF]

Clin Teach
Mohammed Z, Shah MS, Abbas I, Hussain N, Shah S, Chowdry S, Balasubramanian S, Owen K.   +7 more
europepmc   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

From policy to practice: progress towards data- and code-sharing in ecology and evolution. [PDF]

Proc Biol Sci
Ivimey-Cook ER, Sánchez-Tójar A, Berberi I, Culina A, Roche DG, A Almeida R, Amin B, Bairos-Novak KR, Balti H, Bertram MG, Bliard L, Byrne I, Chan YC, Cioffi WR, Corbel Q, Elsy AD, Florko KRN, Gould E, Grainger MJ, Harshbarger AE, Hovstad KA, Martin JM, Martinig AR, Masoero G, Moodie IR, Moreau D, O'Dea RE, Paquet M, Pick JL, Rizvi T, Silva I, Szabo B, Takola E, Thoré ESJ, Verberk WCEP, Windecker SM, Winter G, Zajková Z, Zeiss R, Moran NP.   +39 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source