Results 231 to 240 of about 2,725,232 (305)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

An open letter to the NIH: value and costs in publishing. [PDF]

J Clin Invest
Jackson S, Guth KD, Hawley JB, Williams CL, Hsue PY, Eickelberg O, McNally EM.   +6 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Raising our game: the bare minimum every systematic review publication must meet. [PDF]

BMJ Paediatr Open
Gordon M.
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

RETRACTION: Genetic Causality and Metabolite Pathway Identifying the Relationship of Blood Metabolites and Psoriasis. [PDF]

Skin Res Technol
europepmc   +1 more source

RETRACTION: Serum Lipids May Causally Affect the Occurrence of Alopecia Areata: A Mendelian Randomization Study. [PDF]

Skin Res Technol
europepmc   +1 more source

Early-stage profiles of adolescent mental health difficulties and well-being: A systematic review of cluster analyses in large school and community samples. [PDF]

J Res Adolesc
Bennett M, O'Dwyer C, Eswara-Murthy V, Dalgleish T, Nearchou F.   +4 more
europepmc   +1 more source

Leading practices in the development and delivery of case-based learning programmes for health and social care provider education: a scoping review protocol. [PDF]

BMJ Open
Saari ME, Hudani A, Cardozo V, Giosa JL.
europepmc   +1 more source

RETRACTION: Causal Relationship between Inflammatory Skin Diseases and Breast Cancer: A Bidirectional Mendelian Randomization Study. [PDF]

Skin Res Technol
europepmc   +1 more source