Results 101 to 110 of about 946,633 (311)

Assessing Evidence Quality for Endovascular Arteriovenous Fistulas

Kidney Medicine, 2022
Yoshinosuke Shimamura, MD, MPH, Yasutaka Kuniyoshi, MD, PhD, Yasushi Tsujimoto, MD, MPH   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

An investigation into the benefits of peer coaching: Students supporting students [PDF]

, 2011
There have been many studies carried out which investigate the concepts of coaching and mentoring (Lu, 2010) but there is often confusion between the two models as no clear classification between coaching and mentoring is provided (Fletcher, 2007).
Hooker, Tracey Ann
core  

Longitudinal changes in KL6 levels predict acute exacerbation in fibrotic interstitial lung disease

Scientific Reports
Krebs von den Lungen-6 (KL-6) levels are potentially indicative markers of prospective acute exacerbation (AE) in interstitial lung disease (ILD); however, their longitudinal trends have not been sufficiently investigated.
Akihiro Shiroshita, Keisuke Anan, Chigusa Shirakawa, Hiroshi Shiba, Nobuyuki Yajima   +4 more
doaj   +1 more source

Nationwide spatiotemporal modeling of air pollutants in Japan using generalized random forest models

Environmental Advances
Recent advancements in mixture modeling of air pollutants and their health impacts have underscored the importance of estimating a wide range of air pollutants with high spatiotemporal resolution.
Akihiro Shiroshita, Yuki Kataoka, Keisuke Anan, Nobuyuki Yajima   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Peer support evaluation: a service evaluation of the use of peer support workers at Kent and Medway NHS and Social Care Partnership Trust [PDF]

, 2018
Purpose: Peer Support Workers (PSWs) are an essential component of any Recovery Focused organisation. PSWs are Trust staff who have specifically been employed in KMPT to use their personal experiences of their own mental health challenges in a formal ...
MacInnes, D.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Healthbridge: The National Evaluation of Peer Support Networks and Dementia Advisers in implementation of the National Dementia Strategy for England [PDF]

, 2013
This report, commissioned by the Department of Health, provides evidence on the importance of post diagnostic support for people with dementia and their carers, and the role that dementia advisers and peer support networks can provide in this ...
Hodgson, Philip, Cattan, Mima, Robinson, Louise, Alexjuk, Jo, Wilcockson, Jane, Keyes, Sarah, Reynolds, Joanna, Wilkinson, Heather, McClelland, Siobhan, Corner, Lynne, Clarke, Charlotte   +10 more
core