Results 121 to 130 of about 946,633 (311)

A report highlighting the experiences of peer supporters who deliver, and parents who receive, one-to-one perinatal peer support through Connected CIC [PDF]

Connected Perinatal Support CIC (from hereon in Connected) provides perinatal peer support services across Derby. It offers families assistance in a range of ways, from one-to-one peer support, and in-person and online community groups, including a ...
Montague, J., Barnes, C., Dace, A.
core   +1 more source

Understanding the barriers and facilitators to delivering peer support effectively in England: a qualitative interview study

BMC Psychiatry
Background Peer support roles within mental health services are rapidly increasing in number and scope in the UK and internationally. This paper explores the facilitators and barriers to delivering peer support effectively, as experienced by Peer Support
Una Foye, Natasha Lyons, Prisha Shah, Lizzie Mitchell, Karen Machin, Beverley Chipp, Stephen Jeffreys, Tamar Jeynes, Karen Persaud, Vicky Nicholls, Ruth E. Cooper, Andrew Grundy, Tamara Pemovska, Nafiso Ahmed, Rebecca Appleton, Julie Repper, Sonia Johnson, Brynmor Lloyd-Evans, Alan Simpson   +18 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Understanding the roles and experiences of mental health peer support workers in England: a qualitative interview study

BMC Psychiatry
Background Peer support roles in mental health services are significantly increasing in the United Kingdom and internationally. However, there is wide variation in these roles and limited research exploring the ways in which Peer Support Workers (PSWs ...
Ruth E. Cooper, Natasha Lyons, Stephen Jeffreys, Tamar Jeynes, Vicky Nicholls, Una Foye, Prisha Shah, Lizzie Mitchell, Karen Machin, Beverley Chipp, Andrew Grundy, Tamara Pemovska, Nafiso Ahmed, Rebecca Appleton, Julie Repper, Brynmor Lloyd-Evans, Alan Simpson, Sonia Johnson   +17 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Understanding the role of bystanders and peer support in school bullying [PDF]

, 2014
Research into school bullying has traditionally focussed on the actual protagonists – the perpetrators and the targets. Consequently, we know a great deal about the psychological characteristics of bullies and victims and the consequences of bullying ...
Helen Cowie, Cowie, Helen
core  

Trauma Survivors Network: how does it really work?

Trauma Surgery & Acute Care Open
Trauma centers have the important task of navigating a patient through the complex process of obtaining services and tools for success and addressing important social determinants / drivers of health.
Anna Newcomb, Thomas K Duncan, Glen H Tinkoff, Katherine Joseph, Anastasia Kunac, Peter Anziano   +5 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The fundamentals of a parental peer-to-peer support program in the NICU: a scoping review

Maternal Health, Neonatology and Perinatology
Purpose and background Parental peer support is part of the Family Integrated Care model in NICUs. However, little attention has been devoted to the specific content and organization of parental peer support programs.
A. Pascual, J. M. Wielenga, K. Ruhe, A. H. van Kaam, N. P. Denswil, J. M. Maaskant   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source