Results 41 to 50 of about 946,633 (311)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Study protocol for a randomized trial examining a peer grief support approach for people grieving drug overdose deaths

Addiction Science & Clinical Practice
Background People bereaved by drug overdose experience a “special grief” that includes guilt, shame, and blame for their loved one’s death, which often compounds suffering and interferes with help-seeking.
Karen Chan Osilla, Katherine E. Watkins, Tanya Lord, Glen Lord, Franklin Cook, Katherine Nameth, Jane P. Kim, Wendy Hawkins, Alison Athey   +8 more
doaj   +1 more source

Quality indicators for acute cardiovascular diseases: a scoping review

BMC Health Services Research, 2022
Background Although many quality indicator (QI) sets have been developed for acute cardiovascular diseases, a comprehensive summary is lacking. In this scoping review we aimed to summarize the available evidence on the QI sets for acute cardiovascular ...
Koshiro Kanaoka, Yoshitaka Iwanaga, Yasushi Tsujimoto, Akihiro Shiroshita, Takaaki Suzuki, Michikazu Nakai, Yoshihiro Miyamoto   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Towards a Canonical View of Peer Assessment [PDF]

, 2007
Peer Assessment (or Peer Review) is a popular form of reciprocal assessment where students produce feedback, or grades, for each others work. Peer Assessment activities can be extremely varied with participants taking different roles at different stages ...
Sinclair, Patrick, Lester Gilbert, Senbanjo, Damilola, Howard, Yvonne, Gary B. Wills, Wills, Gary, Yvonne Howard, Patrick Sinclair, Fill, Karen, David E. Millard, Millard, David, Damilola O. Senbanjo, Gilbert, Lester, Karen Fill   +13 more
core   +1 more source

Volunteer peer support frameworks supporting older women living alone [PDF]

, 2022
Volunteer peer support is an approach that enables a supportive connection between volunteers and a sub-set of community members with shared experiences or interests. To implement co-designed strategies to support older women to maintain independence and
Ogrin, Rajna, Green, Maja M, Lowthian, Judy A, Allgood, Helen   +3 more
core   +1 more source

Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta‐analysis

Reproductive Medicine and Biology
Background Follitropin δ may be an alternative to conventional follitropin α/β for controlled ovarian stimulation (COS) within assisted reproductive treatment (ART), but its efficacy and safety remain unknown.
Shinnosuke Komiya, Jun Watanabe, Takero Terayama, Kyosuke Kamijo, Hidetaka Okada   +4 more
doaj   +1 more source

The impact of peer support work on the mental health of peer support specialists

International Journal of Mental Health Systems, 2022
Abstract Background Peers support specialists have positive impacts on the mental health of their service users. However, less is known about how their mental health changes as a result of their activities. Methods We followed 10 peer support specialists over their first ...
Daniel Poremski, Jonathan Han Loong Kuek, Qi Yuan, Ziqiang Li, Kah Lai Yow, Pui Wai Eu, Hong Choon Chua   +6 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source